Site-specific replacement of phosphorothioate with alkyl phosphonate linkages enhances the therapeutic profile of gapmer ASOs by modulating interactions with cellular proteins. [electronic resource]
Producer: 20191125Description: 5465-5479 p. digitalISSN:- 1362-4962
- 3T3-L1 Cells
- Animals
- Caspases -- metabolism
- Cell Line
- Cell Membrane -- metabolism
- Chemokine CXCL12 -- genetics
- Cytoplasm -- metabolism
- DNA-Binding Proteins
- HeLa Cells
- Hepatocytes -- metabolism
- Humans
- Mice
- Mice, Inbred BALB C
- Nuclear Matrix-Associated Proteins -- genetics
- Octamer Transcription Factors -- genetics
- Oligonucleotides, Antisense -- administration & dosage
- Organophosphonates -- chemistry
- Phosphorothioate Oligonucleotides -- administration & dosage
- Protein Binding
- RNA-Binding Proteins -- genetics
- Ribonuclease H -- genetics
- Scavenger Receptors, Class B -- genetics
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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