EGFRvIII upregulates DNA mismatch repair resulting in increased temozolomide sensitivity of MGMT promoter methylated glioblastoma. [electronic resource]
Producer: 20201207Description: 3041-3055 p. digitalISSN:- 1476-5594
- Animals
- Brain Neoplasms -- genetics
- Cell Line, Tumor
- Chemoradiotherapy -- methods
- Cohort Studies
- DNA Methylation
- DNA Mismatch Repair -- drug effects
- DNA Modification Methylases -- genetics
- DNA Repair Enzymes -- genetics
- DNA-Binding Proteins -- genetics
- Drug Resistance, Neoplasm -- genetics
- ErbB Receptors -- genetics
- Female
- Gene Expression Regulation, Neoplastic
- Gene Knockdown Techniques
- Glioblastoma -- genetics
- Humans
- Kaplan-Meier Estimate
- MAP Kinase Signaling System -- genetics
- Mice
- MutS Homolog 2 Protein -- genetics
- Mutation
- Promoter Regions, Genetic -- genetics
- Retrospective Studies
- Temozolomide -- pharmacology
- Tumor Suppressor Proteins -- genetics
- Up-Regulation
- Xenograft Model Antitumor Assays
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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