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Synthesis and biological activity of 5-aryl-4-(4-(5-methyl-1H-imidazol-4-yl)piperidin-1-yl)pyrimidine analogs as potent, highly selective, and orally bioavailable NHE-1 inhibitors. [electronic resource] by
- Atwal, Karnail S
- O'Neil, Steven V
- Ahmad, Saleem
- Doweyko, Lidia
- Kirby, Mark
- Dorso, Charles R
- Chandrasena, Gamini
- Chen, Bang-Chi
- Zhao, Rulin
- Zahler, Robert
Producer: 20061016
In:
Bioorganic & medicinal chemistry letters vol. 16
Availability: No items available.
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Design and synthesis of novel N-sulfonyl-2-indole carboxamides as potent PPAR-gamma binding agents with potential application to the treatment of osteoporosis. [electronic resource] by
- Hopkins, Corey R
- O'neil, Steven V
- Laufersweiler, Michael C
- Wang, Yili
- Pokross, Matthew
- Mekel, Marlene
- Evdokimov, Artem
- Walter, Richard
- Kontoyianni, Maria
- Petrey, Maria E
- Sabatakos, Georgios
- Roesgen, Jeff T
- Richardson, Eloise
- Demuth, Thomas P
Producer: 20061222
In:
Bioorganic & medicinal chemistry letters vol. 16
Availability: No items available.
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Synthesis and evaluation of thiazepines as interleukin-1beta converting enzyme (ICE) inhibitors. [electronic resource] by
- Ellis, Christopher D
- Oppong, Kofi A
- Laufersweiler, Michael C
- O'Neil, Steven V
- Soper, David L
- Wang, Yili
- Wos, John A
- Fancher, Amy N
- Lu, Wei
- Suchanek, Maureen K
- Wang, Richard L
- De, Biswanath
- Demuth, Thomas P
Producer: 20061016
In:
Bioorganic & medicinal chemistry letters vol. 16
Availability: No items available.
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6.
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Synthesis and evaluation of tricyclic pyrrolopyrimidinones as dipeptide mimetics: inhibition of interleukin-1beta-converting enzyme. [electronic resource] by
- Laufersweiler, Michael C
- Wang, Yili
- Soper, David L
- Suchanek, Maureen K
- Fancher, Amy N
- Lu, Wei
- Wang, Richard L
- Oppong, Kofi A
- Ellis, Christopher D
- Baize, Mark W
- O'Neil, Steven V
- Wos, John A
- Demuth, Thomas P
Producer: 20051220
In:
Bioorganic & medicinal chemistry letters vol. 15
Availability: No items available.
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Synthesis and evaluation of novel 1-(2-acylhydrazinocarbonyl)-cycloalkyl carboxamides as interleukin-1beta converting enzyme (ICE) inhibitors. [electronic resource] by
- Soper, David L
- Sheville, Justin
- O'Neil, Steven V
- Wang, Yili
- Laufersweiler, Michael C
- Oppong, Kofi A
- Wos, John A
- Ellis, Christopher D
- Fancher, Amy N
- Lu, Wei
- Suchanek, Maureen K
- Wang, Richard L
- De, Biswanath
- Demuth, Thomas P
Producer: 20061006
In:
Bioorganic & medicinal chemistry letters vol. 16
Availability: No items available.
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8.
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Synthesis and evaluation of novel 8,6-fused bicyclic peptidomimetic compounds as interleukin-1beta converting enzyme inhibitors. [electronic resource] by
- O'Neil, Steven V
- Wang, Yili
- Laufersweiler, Michael C
- Oppong, Kofi A
- Soper, David L
- Wos, John A
- Ellis, Christopher D
- Baize, Mark W
- Bosch, Gregory K
- Fancher, Amy N
- Lu, Wei
- Suchanek, Maureen K
- Wang, Richard L
- De, Biswanath
- Demuth, Thomas P
Producer: 20060627
In:
Bioorganic & medicinal chemistry letters vol. 15
Availability: No items available.
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9.
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Discovery of novel conformationally restricted diazocan peptidomimetics as inhibitors of interleukin-1beta synthesis. [electronic resource] by
- Oppong, Kofi A
- Ellis, Christopher D
- Laufersweiler, Michael C
- O'Neil, Steven V
- Wang, Yili
- Soper, David L
- Baize, Mark W
- Wos, John A
- De, Biswanath
- Bosch, Gregory K
- Fancher, Amy N
- Lu, Wei
- Suchanek, Maureen K
- Wang, Richard L
- Demuth, Thomas P
Producer: 20051220
In:
Bioorganic & medicinal chemistry letters vol. 15
Availability: No items available.
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Synthesis and evaluation of unsaturated caprolactams as interleukin-1beta converting enzyme (ICE) inhibitors. [electronic resource] by
- Wang, Yili
- O'Neil, Steven V
- Wos, John A
- Oppong, Kofi A
- Laufersweiler, Michael C
- Soper, David L
- Ellis, Christopher D
- Baize, Mark W
- Fancher, Amy N
- Lu, Wei
- Suchanek, Maureen K
- Wang, Richard L
- Schwecke, William P
- Cruze, Charles A
- Buchalova, Maria
- Belkin, Marina
- De, Biswanath
- Demuth, Thomas P
Producer: 20070405
In:
Bioorganic & medicinal chemistry vol. 15
Availability: No items available.
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11.
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Design and Synthesis of γ- and δ-Lactam M [electronic resource] by
- Davoren, Jennifer E
- Garnsey, Michelle
- Pettersen, Betty
- Brodney, Michael A
- Edgerton, Jeremy R
- Fortin, Jean-Philippe
- Grimwood, Sarah
- Harris, Anthony R
- Jenkinson, Stephen
- Kenakin, Terry
- Lazzaro, John T
- Lee, Che-Wah
- Lotarski, Susan M
- Nottebaum, Lisa
- O'Neil, Steven V
- Popiolek, Michael
- Ramsey, Simeon
- Steyn, Stefanus J
- Thorn, Catherine A
- Zhang, Lei
- Webb, Damien
Producer: 20170905
In:
Journal of medicinal chemistry vol. 60
Availability: No items available.
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12.
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Synthesis and evaluation of novel 8,5-fused bicyclic peptidomimetic compounds as interleukin-1beta converting enzyme (ICE) inhibitors. [electronic resource] by
- Soper, David L
- Sheville, Justin X
- O'Neil, Steven V
- Wang, Yili
- Laufersweiler, Michael C
- Oppong, Kofi A
- Wos, John A
- Ellis, Christopher D
- Baize, Mark W
- Chen, Jack J
- Fancher, Amy N
- Lu, Wei
- Suchanek, Maureen K
- Wang, Richard L
- Schwecke, William P
- Cruze, Charles A
- Buchalova, Maria
- Belkin, Marina
- Wireko, Fred
- Ritter, Amanda
- De, Biswanath
- Wang, Difei
- Demuth, Thomas P
Producer: 20070130
In:
Bioorganic & medicinal chemistry vol. 14
Availability: No items available.
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13.
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Design and optimization of selective azaindole amide M1 positive allosteric modulators. [electronic resource] by
- Davoren, Jennifer E
- O'Neil, Steven V
- Anderson, Dennis P
- Brodney, Michael A
- Chenard, Lois
- Dlugolenski, Keith
- Edgerton, Jeremy R
- Green, Michael
- Garnsey, Michelle
- Grimwood, Sarah
- Harris, Anthony R
- Kauffman, Gregory W
- LaChapelle, Erik
- Lazzaro, John T
- Lee, Che-Wah
- Lotarski, Susan M
- Nason, Deane M
- Obach, R Scott
- Reinhart, Veronica
- Salomon-Ferrer, Romelia
- Steyn, Stefanus J
- Webb, Damien
- Yan, Jiangli
- Zhang, Lei
Producer: 20161011
In:
Bioorganic & medicinal chemistry letters vol. 26
Availability: No items available.
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14.
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Discovery of Trifluoromethyl Glycol Carbamates as Potent and Selective Covalent Monoacylglycerol Lipase (MAGL) Inhibitors for Treatment of Neuroinflammation. [electronic resource] by
- McAllister, Laura A
- Butler, Christopher R
- Mente, Scot
- O'Neil, Steven V
- Fonseca, Kari R
- Piro, Justin R
- Cianfrogna, Julie A
- Foley, Timothy L
- Gilbert, Adam M
- Harris, Anthony R
- Helal, Christopher J
- Johnson, Douglas S
- Montgomery, Justin I
- Nason, Deane M
- Noell, Stephen
- Pandit, Jayvardhan
- Rogers, Bruce N
- Samad, Tarek A
- Shaffer, Christopher L
- da Silva, Rafael G
- Uccello, Daniel P
- Webb, Damien
- Brodney, Michael A
Producer: 20190417
In:
Journal of medicinal chemistry vol. 61
Availability: No items available.
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15.
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Discovery of the Potent and Selective M1 PAM-Agonist N-[(3R,4S)-3-Hydroxytetrahydro-2H-pyran-4-yl]-5-methyl-4-[4-(1,3-thiazol-4-yl)benzyl]pyridine-2-carboxamide (PF-06767832): Evaluation of Efficacy and Cholinergic Side Effects. [electronic resource] by
- Davoren, Jennifer E
- Lee, Che-Wah
- Garnsey, Michelle
- Brodney, Michael A
- Cordes, Jason
- Dlugolenski, Keith
- Edgerton, Jeremy R
- Harris, Anthony R
- Helal, Christopher J
- Jenkinson, Stephen
- Kauffman, Gregory W
- Kenakin, Terrence P
- Lazzaro, John T
- Lotarski, Susan M
- Mao, Yuxia
- Nason, Deane M
- Northcott, Carrie
- Nottebaum, Lisa
- O'Neil, Steven V
- Pettersen, Betty
- Popiolek, Michael
- Reinhart, Veronica
- Salomon-Ferrer, Romelia
- Steyn, Stefanus J
- Webb, Damien
- Zhang, Lei
- Grimwood, Sarah
Producer: 20170529
In:
Journal of medicinal chemistry vol. 59
Availability: No items available.
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