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Prediction of non-linear pharmacokinetics in humans of an antibody-drug conjugate (ADC) when evaluation of higher doses in animals is limited by tolerability: Case study with an anti-CD33 ADC. [electronic resource] by
- Figueroa, Isabel
- Leipold, Doug
- Leong, Steve
- Zheng, Bing
- Triguero-Carrasco, Montserrat
- Fourie-O'Donohue, Aimee
- Kozak, Katherine R
- Xu, Keyang
- Schutten, Melissa
- Wang, Hong
- Polson, Andrew G
- Kamath, Amrita V
Producer: 20190318
In:
mAbs vol. 10
Availability: No items available.
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3.
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Mechanism-Based Pharmacokinetic/Pharmacodynamic Model for THIOMAB™ Drug Conjugates. [electronic resource] by
- Sukumaran, Siddharth
- Gadkar, Kapil
- Zhang, Crystal
- Bhakta, Sunil
- Liu, Luna
- Xu, Keyang
- Raab, Helga
- Yu, Shang-Fan
- Mai, Elaine
- Fourie-O'Donohue, Aimee
- Kozak, Katherine R
- Ramanujan, Saroja
- Junutula, Jagath R
- Lin, Kedan
Producer: 20160414
In:
Pharmaceutical research vol. 32
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4.
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Catalytic Cleavage of Disulfide Bonds in Small Molecules and Linkers of Antibody-Drug Conjugates. [electronic resource] by
- Zhang, Donglu
- Fourie-O'Donohue, Aimee
- Dragovich, Peter S
- Pillow, Thomas H
- Sadowsky, Jack D
- Kozak, Katherine R
- Cass, Robert T
- Liu, Liling
- Deng, Yuzhong
- Liu, Yichin
- Hop, Cornelis E C A
- Khojasteh, S Cyrus
Producer: 20200601
In:
Drug metabolism and disposition: the biological fate of chemicals vol. 47
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Total antibody quantification for MMAE-conjugated antibody-drug conjugates: impact of assay format and reagents. [electronic resource] by
- Kozak, Katherine R
- Tsai, Siao Ping
- Fourie-O'Donohue, Aimee
- dela Cruz Chuh, Josefa
- Roth, Leslie
- Cook, Ryan
- Chan, Elton
- Chan, Pamela
- Darwish, Martine
- Ohri, Rachana
- Raab, Helga
- Zhang, Crystal
- Lin, Kedan
- Wong, Wai Lee T
Producer: 20131125
In:
Bioconjugate chemistry vol. 24
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6.
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Biodistribution and efficacy of an anti-TENB2 antibody-drug conjugate in a patient-derived model of prostate cancer. [electronic resource] by
- Boswell, C Andrew
- Yadav, Daniela Bumbaca
- Mundo, Eduardo E
- Yu, Shang-Fan
- Lacap, Jennifer Arca
- Fourie-O'Donohue, Aimee
- Kozak, Katherine R
- Ferl, Gregory Z
- Zhang, Crystal
- Ho, Jason
- Ulufatu, Sheila
- Khawli, Leslie A
- Lin, Kedan
Publication details: Oncotarget Oct 2019
In:
Oncotarget vol. 10
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Improved translation of stability for conjugated antibodies using an in vitro whole blood assay. [electronic resource] by
- Fourie-O'Donohue, Aimee
- Chu, Phillip Y
- Dela Cruz Chuh, Josefa
- Tchelepi, Robert
- Tsai, Siao Ping
- Tran, John C
- Sawyer, William S
- Su, Dian
- Ng, Carl
- Xu, Keyang
- Yu, Shang-Fan
- Pillow, Thomas H
- Sadowsky, Jack
- Dragovich, Peter S
- Liu, Yichin
- Kozak, Katherine R
Producer: 20210212
In:
mAbs vol. 12
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An antimesothelin-monomethyl auristatin e conjugate with potent antitumor activity in ovarian, pancreatic, and mesothelioma models. [electronic resource] by
- Scales, Suzie J
- Gupta, Nidhi
- Pacheco, Glenn
- Firestein, Ron
- French, Dorothy M
- Koeppen, Hartmut
- Rangell, Linda
- Barry-Hamilton, Vivian
- Luis, Elizabeth
- Chuh, Josefa
- Zhang, Yin
- Ingle, Gladys S
- Fourie-O'Donohue, Aimee
- Kozak, Katherine R
- Ross, Sarajane
- Dennis, Mark S
- Spencer, Susan D
Producer: 20151110
In:
Molecular cancer therapeutics vol. 13
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Attachment Site Cysteine Thiol pK [electronic resource] by
- Vollmar, Breanna S
- Wei, Binqing
- Ohri, Rachana
- Zhou, Jianhui
- He, Jintang
- Yu, Shang-Fan
- Leipold, Douglas
- Cosino, Ely
- Yee, Sharon
- Fourie-O'Donohue, Aimee
- Li, Guangmin
- Phillips, Gail L
- Kozak, Katherine R
- Kamath, Amrita
- Xu, Keyang
- Lee, Genee
- Lazar, Greg A
- Erickson, Hans K
Producer: 20171107
In:
Bioconjugate chemistry vol. 28
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10.
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High-Throughput Cysteine Scanning To Identify Stable Antibody Conjugation Sites for Maleimide- and Disulfide-Based Linkers. [electronic resource] by
- Ohri, Rachana
- Bhakta, Sunil
- Fourie-O'Donohue, Aimee
- Dela Cruz-Chuh, Josefa
- Tsai, Siao Ping
- Cook, Ryan
- Wei, Binqing
- Ng, Carl
- Wong, Athena W
- Bos, Aaron B
- Farahi, Farzam
- Bhakta, Jiten
- Pillow, Thomas H
- Raab, Helga
- Vandlen, Richard
- Polakis, Paul
- Liu, Yichin
- Erickson, Hans
- Junutula, Jagath R
- Kozak, Katherine R
Producer: 20180917
In:
Bioconjugate chemistry vol. 29
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Targeted drug delivery through the traceless release of tertiary and heteroaryl amines from antibody-drug conjugates. [electronic resource] by
- Staben, Leanna R
- Koenig, Stefan G
- Lehar, Sophie M
- Vandlen, Richard
- Zhang, Donglu
- Chuh, Josefa
- Yu, Shang-Fan
- Ng, Carl
- Guo, Jun
- Liu, Yanzhou
- Fourie-O'Donohue, Aimee
- Go, MaryAnn
- Linghu, Xin
- Segraves, Nathaniel L
- Wang, Tao
- Chen, Jinhua
- Wei, BinQing
- Phillips, Gail D Lewis
- Xu, Keyang
- Kozak, Katherine R
- Mariathasan, Sanjeev
- Flygare, John A
- Pillow, Thomas H
Producer: 20180820
In:
Nature chemistry vol. 8
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12.
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Correction: An Anti-GDNF Family Receptor Alpha 1 (GFRA1) Antibody-Drug Conjugate for the Treatment of Hormone Receptor-Positive Breast Cancer. [electronic resource] by
- Bhakta, Sunil
- Crocker, Lisa M
- Chen, Yvonne
- Hazen, Meredith
- Schutten, Melissa M
- Li, Dongwei
- Kuijl, Coenraad
- Ohri, Rachana
- Zhong, Fiona
- Poon, Kirsten A
- Go, Mary Ann T
- Cheng, Eric
- Piskol, Robert
- Firestein, Ron
- Fourie-O'Donohue, Aimee
- Kozak, Katherine R
- Raab, Helga
- Hongo, Jo-Anne
- Sampath, Deepak
- Dennis, Mark S
- Scheller, Richard H
- Polakis, Paul
- Junutula, Jagath R
Publication details: Molecular cancer therapeutics Nov 2019
In:
Molecular cancer therapeutics vol. 18
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13.
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An Anti-GDNF Family Receptor Alpha 1 (GFRA1) Antibody-Drug Conjugate for the Treatment of Hormone Receptor-Positive Breast Cancer. [electronic resource] by
- Bhakta, Sunil
- Crocker, Lisa M
- Chen, Yvonne
- Hazen, Meredith
- Schutten, Melissa M
- Li, Dongwei
- Kuijl, Coenraad
- Ohri, Rachana
- Zhong, Fiona
- Poon, Kirsten A
- Go, Mary Ann T
- Cheng, Eric
- Piskol, Robert
- Firestein, Ron
- Fourie-O'Donohue, Aimee
- Kozak, Katherine R
- Raab, Helga
- Hongo, Jo-Anne
- Sampath, Deepak
- Dennis, Mark S
- Scheller, Richard H
- Polakis, Paul
- Junutula, Jagath R
Producer: 20190409
In:
Molecular cancer therapeutics vol. 17
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14.
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Modulating Antibody-Drug Conjugate Payload Metabolism by Conjugation Site and Linker Modification. [electronic resource] by
- Su, Dian
- Kozak, Katherine R
- Sadowsky, Jack
- Yu, Shang-Fan
- Fourie-O'Donohue, Aimee
- Nelson, Christopher
- Vandlen, Richard
- Ohri, Rachana
- Liu, Luna
- Ng, Carl
- He, Jintang
- Davis, Helen
- Lau, Jeff
- Del Rosario, Geoffrey
- Cosino, Ely
- Cruz-Chuh, Josefa Dela
- Ma, Yong
- Zhang, Donglu
- Darwish, Martine
- Cai, Wenwen
- Chen, Chunjiao
- Zhou, Hongxiang
- Lu, Jiawei
- Liu, Yichin
- Kaur, Surinder
- Xu, Keyang
- Pillow, Thomas H
Producer: 20190405
In:
Bioconjugate chemistry vol. 29
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15.
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Development of Efficient Chemistry to Generate Site-Specific Disulfide-Linked Protein- and Peptide-Payload Conjugates: Application to THIOMAB Antibody-Drug Conjugates. [electronic resource] by
- Sadowsky, Jack D
- Pillow, Thomas H
- Chen, Jinhua
- Fan, Fang
- He, Changrong
- Wang, Yanli
- Yan, Gang
- Yao, Hui
- Xu, Zijin
- Martin, Shanique
- Zhang, Donglu
- Chu, Phillip
- Dela Cruz-Chuh, Josefa
- O'Donohue, Aimee
- Li, Guangmin
- Del Rosario, Geoffrey
- He, Jintang
- Liu, Luna
- Ng, Carl
- Su, Dian
- Lewis Phillips, Gail D
- Kozak, Katherine R
- Yu, Shang-Fan
- Xu, Keyang
- Leipold, Douglas
- Wai, John
Producer: 20170912
In:
Bioconjugate chemistry vol. 28
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16.
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Site-specific trastuzumab maytansinoid antibody-drug conjugates with improved therapeutic activity through linker and antibody engineering. [electronic resource] by
- Pillow, Thomas H
- Tien, Janet
- Parsons-Reponte, Kathryn L
- Bhakta, Sunil
- Li, Hao
- Staben, Leanna R
- Li, Guangmin
- Chuh, Josefa
- Fourie-O'Donohue, Aimee
- Darwish, Martine
- Yip, Victor
- Liu, Luna
- Leipold, Douglas D
- Su, Dian
- Wu, Elmer
- Spencer, Susan D
- Shen, Ben-Quan
- Xu, Keyang
- Kozak, Katherine R
- Raab, Helga
- Vandlen, Richard
- Lewis Phillips, Gail D
- Scheller, Richard H
- Polakis, Paul
- Sliwkowski, Mark X
- Flygare, John A
- Junutula, Jagath R
Producer: 20141218
In:
Journal of medicinal chemistry vol. 57
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17.
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Antibody Conjugation of a Chimeric BET Degrader Enables in vivo Activity. [electronic resource] by
- Pillow, Thomas H
- Adhikari, Pragya
- Blake, Robert A
- Chen, Jinhua
- Del Rosario, Geoffrey
- Deshmukh, Gauri
- Figueroa, Isabel
- Gascoigne, Karen E
- Kamath, Amrita V
- Kaufman, Susan
- Kleinheinz, Tracy
- Kozak, Katherine R
- Latifi, Brandon
- Leipold, Douglas D
- Sing Li, Chun
- Li, Ruina
- Mulvihill, Melinda M
- O'Donohue, Aimee
- Rowntree, Rebecca K
- Sadowsky, Jack D
- Wai, John
- Wang, Xinxin
- Wu, Cong
- Xu, Zijin
- Yao, Hui
- Yu, Shang-Fan
- Zhang, Donglu
- Zang, Richard
- Zhang, Hongyan
- Zhou, Hao
- Zhu, Xiaoyu
- Dragovich, Peter S
Producer: 20210128
In:
ChemMedChem vol. 15
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Exploration of Pyrrolobenzodiazepine (PBD)-Dimers Containing Disulfide-Based Prodrugs as Payloads for Antibody-Drug Conjugates. [electronic resource] by
- Pei, Zhonghua
- Chen, Chunjiao
- Chen, Jinhua
- Cruz-Chuh, Josefa Dela
- Delarosa, Reginald
- Deng, Yuzhong
- Fourie-O'Donohue, Aimee
- Figueroa, Isabel
- Guo, Jun
- Jin, Weiwei
- Khojasteh, S Cyrus
- Kozak, Katherine R
- Latifi, Brandon
- Lee, James
- Li, Guangmin
- Lin, Eva
- Liu, Liling
- Lu, Jiawei
- Martin, Scott
- Ng, Carl
- Nguyen, Trung
- Ohri, Rachana
- Lewis Phillips, Gail
- Pillow, Thomas H
- Rowntree, Rebecca K
- Stagg, Nicola J
- Stokoe, David
- Ulufatu, Sheila
- Verma, Vishal A
- Wai, John
- Wang, Jing
- Xu, Keyang
- Xu, Zijin
- Yao, Hui
- Yu, Shang-Fan
- Zhang, Donglu
- Dragovich, Peter S
Producer: 20190802
In:
Molecular pharmaceutics vol. 15
Availability: No items available.
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