WEE1 Kinase Inhibitor AZD1775 Has Preclinical Efficacy in LKB1-Deficient Non-Small Cell Lung Cancer. [electronic resource]
Producer: 20171031Description: 4663-4672 p. digitalISSN:- 1538-7445
- AMP-Activated Protein Kinases
- Animals
- Carcinoma, Non-Small-Cell Lung -- drug therapy
- Cell Cycle Checkpoints -- drug effects
- Cell Cycle Proteins -- antagonists & inhibitors
- Cell Survival -- drug effects
- Drug Evaluation, Preclinical
- Female
- Humans
- Lung Neoplasms -- drug therapy
- Male
- Mice
- Mice, Transgenic
- Mutation -- genetics
- Nuclear Proteins -- antagonists & inhibitors
- Phosphorylation -- drug effects
- Protein Serine-Threonine Kinases -- deficiency
- Protein-Tyrosine Kinases -- antagonists & inhibitors
- Proto-Oncogene Proteins p21(ras) -- genetics
- Pyrazoles -- pharmacology
- Pyrimidines -- pharmacology
- Pyrimidinones
- Tumor Cells, Cultured
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Publication Type: Journal Article
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