Results
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Substituted 6-phenyl-pyridin-2-ylamines: selective and potent inhibitors of neuronal nitric oxide synthase. [electronic resource] by
- Nason, Deane M
- Heck, Steven D
- Bodenstein, Mathew S
- Lowe, John A
- Nelson, Robert B
- Liston, Dane R
- Nolan, Charles E
- Lanyon, Lorraine F
- Ward, Karen M
- Volkmann, Robert A
Producer: 20050209
In:
Bioorganic & medicinal chemistry letters vol. 14
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3.
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Anesthesia leads to tau hyperphosphorylation through inhibition of phosphatase activity by hypothermia. [electronic resource] by
- Planel, Emmanuel
- Richter, Karl E G
- Nolan, Charles E
- Finley, James E
- Liu, Li
- Wen, Yi
- Krishnamurthy, Pavan
- Herman, Mathieu
- Wang, Lili
- Schachter, Joel B
- Nelson, Robert B
- Lau, Lit-Fui
- Duff, Karen E
Producer: 20070412
In:
The Journal of neuroscience : the official journal of the Society for Neuroscience vol. 27
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4.
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Quantitative pharmacokinetic/pharmacodynamic analyses suggest that the 129/SVE mouse is a suitable preclinical pharmacology model for identifying small-molecule γ-secretase inhibitors. [electronic resource] by
- Lu, Yasong
- Zhang, Liming
- Nolan, Charles E
- Becker, Stacey L
- Atchison, Kevin
- Robshaw, Ashley E
- Pustilnik, Leslie R
- Osgood, Sarah M
- Miller, Emily H
- Stepan, Antonia F
- Subramanyam, Chakrapani
- Efremov, Ivan
- Hallgren, Andrew J
- Riddell, David
Producer: 20120112
In:
The Journal of pharmacology and experimental therapeutics vol. 339
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5.
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Quantitative Analysis of [electronic resource] by
- Takano, Akihiro
- Chen, Laigao
- Nag, Sangram
- Brodney, Michael A
- Arakawa, Ryosuke
- Chang, Cheng
- Amini, Nahid
- Doran, Shawn D
- Dutra, Jason K
- McCarthy, Timothy J
- Nolan, Charles E
- O'Neill, Brian T
- Villalobos, Anabella
- Zhang, Lei
- Halldin, Christer
Producer: 20200330
In:
Journal of nuclear medicine : official publication, Society of Nuclear Medicine vol. 60
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6.
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Cerebrospinal fluid β-Amyloid turnover in the mouse, dog, monkey and human evaluated by systematic quantitative analyses. [electronic resource] by
- Lu, Yasong
- Barton, Hugh A
- Leung, Louis
- Zhang, Liming
- Hajos-Korcsok, Eva
- Nolan, Charles E
- Liu, Jianhua
- Becker, Stacey L
- Wood, Kathleen M
- Robshaw, Ashley E
- Taylor, Christine K
- O'Neill, Brian T
- Brodney, Michael A
- Riddell, David
Producer: 20140102
In:
Neuro-degenerative diseases vol. 12
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7.
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Spirocyclic sulfamides as β-secretase 1 (BACE-1) inhibitors for the treatment of Alzheimer's disease: utilization of structure based drug design, WaterMap, and CNS penetration studies to identify centrally efficacious inhibitors. [electronic resource] by
- Brodney, Michael A
- Barreiro, Gabriela
- Ogilvie, Kevin
- Hajos-Korcsok, Eva
- Murray, John
- Vajdos, Felix
- Ambroise, Claude
- Christoffersen, Curt
- Fisher, Katherine
- Lanyon, Lorraine
- Liu, Jianhua
- Nolan, Charles E
- Withka, Jane M
- Borzilleri, Kris A
- Efremov, Ivan
- Oborski, Christine E
- Varghese, Alison
- O'Neill, Brian T
Producer: 20130226
In:
Journal of medicinal chemistry vol. 55
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8.
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Cerebrospinal fluid amyloid-β (Aβ) as an effect biomarker for brain Aβ lowering verified by quantitative preclinical analyses. [electronic resource] by
- Lu, Yasong
- Riddell, David
- Hajos-Korcsok, Eva
- Bales, Kelly
- Wood, Kathleen M
- Nolan, Charles E
- Robshaw, Ashley E
- Zhang, Liming
- Leung, Louis
- Becker, Stacey L
- Tseng, Elaine
- Barricklow, Jason
- Miller, Emily H
- Osgood, Sarah
- O'Neill, Brian T
- Brodney, Michael A
- Johnson, Douglas S
- Pettersson, Martin
Producer: 20121221
In:
The Journal of pharmacology and experimental therapeutics vol. 342
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9.
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Identification of a Novel Positron Emission Tomography (PET) Ligand for Imaging β-Site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE-1) in Brain. [electronic resource] by
- Zhang, Lei
- Chen, Laigao
- Dutra, Jason K
- Beck, Elizabeth M
- Nag, Sangram
- Takano, Akihiro
- Amini, Nahid
- Arakawa, Ryosuke
- Brodney, Michael A
- Buzon, Leanne M
- Doran, Shawn D
- Lanyon, Lorraine F
- McCarthy, Timothy J
- Bales, Kelly R
- Nolan, Charles E
- O'Neill, Brian T
- Schildknegt, Klaas
- Halldin, Christer
- Villalobos, Anabella
Producer: 20190423
In:
Journal of medicinal chemistry vol. 61
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10.
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Pharmacodynamics and pharmacokinetics of the gamma-secretase inhibitor PF-3084014. [electronic resource] by
- Lanz, Thomas A
- Wood, Kathleen M
- Richter, Karl E G
- Nolan, Charles E
- Becker, Stacey L
- Pozdnyakov, Nikolay
- Martin, Barbara-Anne
- Du, Ping
- Oborski, Christine E
- Wood, Douglas E
- Brown, Tracy M
- Finley, James E
- Sokolowski, Sharon A
- Hicks, Carol D
- Coffman, Karen J
- Geoghegan, Kieran F
- Brodney, Michael A
- Liston, Dane
- Tate, Barbara
Producer: 20100713
In:
The Journal of pharmacology and experimental therapeutics vol. 334
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11.
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Aminomethyl-Derived Beta Secretase (BACE1) Inhibitors: Engaging Gly230 without an Anilide Functionality. [electronic resource] by
- Butler, Christopher R
- Ogilvie, Kevin
- Martinez-Alsina, Luis
- Barreiro, Gabriela
- Beck, Elizabeth M
- Nolan, Charles E
- Atchison, Kevin
- Benvenuti, Eric
- Buzon, Leanne
- Doran, Shawn
- Gonzales, Cathleen
- Helal, Christopher J
- Hou, Xinjun
- Hsu, Mei-Hui
- Johnson, Eric F
- Lapham, Kimberly
- Lanyon, Lorraine
- Parris, Kevin
- O'Neill, Brian T
- Riddell, David
- Robshaw, Ashley
- Vajdos, Felix
- Brodney, Michael A
Producer: 20170807
In:
Journal of medicinal chemistry vol. 60
Availability: No items available.
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12.
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Chemoproteomic profiling reveals that cathepsin D off-target activity drives ocular toxicity of β-secretase inhibitors. [electronic resource] by
- Zuhl, Andrea M
- Nolan, Charles E
- Brodney, Michael A
- Niessen, Sherry
- Atchison, Kevin
- Houle, Christopher
- Karanian, David A
- Ambroise, Claude
- Brulet, Jeffrey W
- Beck, Elizabeth M
- Doran, Shawn D
- O'Neill, Brian T
- Am Ende, Christopher W
- Chang, Cheng
- Geoghegan, Kieran F
- West, Graham M
- Judkins, Joshua C
- Hou, Xinjun
- Riddell, David R
- Johnson, Douglas S
Producer: 20180905
In:
Nature communications vol. 7
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13.
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Concentration-dependent modulation of amyloid-beta in vivo and in vitro using the gamma-secretase inhibitor, LY-450139. [electronic resource] by
- Lanz, Thomas A
- Karmilowicz, Michael J
- Wood, Kathleen M
- Pozdnyakov, Nikolay
- Du, Ping
- Piotrowski, Mary A
- Brown, Tracy M
- Nolan, Charles E
- Richter, Karl E G
- Finley, James E
- Fei, Qing
- Ebbinghaus, Charles F
- Chen, Yuhpyng L
- Spracklin, Douglas K
- Tate, Barbara
- Geoghegan, Kieran F
- Lau, Lit-Fui
- Auperin, David D
- Schachter, Joel B
Producer: 20061204
In:
The Journal of pharmacology and experimental therapeutics vol. 319
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14.
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Discovery of a series of efficient, centrally efficacious BACE1 inhibitors through structure-based drug design. [electronic resource] by
- Butler, Christopher R
- Brodney, Michael A
- Beck, Elizabeth M
- Barreiro, Gabriela
- Nolan, Charles E
- Pan, Feng
- Vajdos, Felix
- Parris, Kevin
- Varghese, Alison H
- Helal, Christopher J
- Lira, Ricardo
- Doran, Shawn D
- Riddell, David R
- Buzon, Leanne M
- Dutra, Jason K
- Martinez-Alsina, Luis A
- Ogilvie, Kevin
- Murray, John C
- Young, Joseph M
- Atchison, Kevin
- Robshaw, Ashley
- Gonzales, Cathleen
- Wang, Jinlong
- Zhang, Yong
- O'Neill, Brian T
Producer: 20150526
In:
Journal of medicinal chemistry vol. 58
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15.
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Metabolism-directed design of oxetane-containing arylsulfonamide derivatives as γ-secretase inhibitors. [electronic resource] by
- Stepan, Antonia F
- Karki, Kapil
- McDonald, W Scott
- Dorff, Peter H
- Dutra, Jason K
- Dirico, Kenneth J
- Won, Annie
- Subramanyam, Chakrapani
- Efremov, Ivan V
- O'Donnell, Christopher J
- Nolan, Charles E
- Becker, Stacey L
- Pustilnik, Leslie R
- Sneed, Blossom
- Sun, Hao
- Lu, Yasong
- Robshaw, Ashley E
- Riddell, David
- O'Sullivan, Theresa J
- Sibley, Evelyn
- Capetta, Steven
- Atchison, Kevin
- Hallgren, Andrew J
- Miller, Emily
- Wood, Anthony
- Obach, R Scott
Producer: 20120207
In:
Journal of medicinal chemistry vol. 54
Availability: No items available.
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16.
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Application of the bicyclo[1.1.1]pentane motif as a nonclassical phenyl ring bioisostere in the design of a potent and orally active γ-secretase inhibitor. [electronic resource] by
- Stepan, Antonia F
- Subramanyam, Chakrapani
- Efremov, Ivan V
- Dutra, Jason K
- O'Sullivan, Theresa J
- DiRico, Kenneth J
- McDonald, W Scott
- Won, Annie
- Dorff, Peter H
- Nolan, Charles E
- Becker, Stacey L
- Pustilnik, Leslie R
- Riddell, David R
- Kauffman, Gregory W
- Kormos, Bethany L
- Zhang, Liming
- Lu, Yasong
- Capetta, Steven H
- Green, Michael E
- Karki, Kapil
- Sibley, Evelyn
- Atchison, Kevin P
- Hallgren, Andrew J
- Oborski, Christine E
- Robshaw, Ashley E
- Sneed, Blossom
- O'Donnell, Christopher J
Producer: 20120831
In:
Journal of medicinal chemistry vol. 55
Availability: No items available.
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17.
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Utilizing structures of CYP2D6 and BACE1 complexes to reduce risk of drug-drug interactions with a novel series of centrally efficacious BACE1 inhibitors. [electronic resource] by
- Brodney, Michael A
- Beck, Elizabeth M
- Butler, Christopher R
- Barreiro, Gabriela
- Johnson, Eric F
- Riddell, David
- Parris, Kevin
- Nolan, Charles E
- Fan, Ying
- Atchison, Kevin
- Gonzales, Cathleen
- Robshaw, Ashley E
- Doran, Shawn D
- Bundesmann, Mark W
- Buzon, Leanne
- Dutra, Jason
- Henegar, Kevin
- LaChapelle, Erik
- Hou, Xinjun
- Rogers, Bruce N
- Pandit, Jayvardhan
- Lira, Ricardo
- Martinez-Alsina, Luis
- Mikochik, Peter
- Murray, John C
- Ogilvie, Kevin
- Price, Loren
- Sakya, Subas M
- Yu, Aijia
- Zhang, Yong
- O'Neill, Brian T
Producer: 20150630
In:
Journal of medicinal chemistry vol. 58
Availability: No items available.
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18.
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Diamide amino-imidazoles: a novel series of γ-secretase inhibitors for the treatment of Alzheimer's disease. [electronic resource] by
- Brodney, Michael A
- Auperin, David D
- Becker, Stacey L
- Bronk, Brian S
- Brown, Tracy M
- Coffman, Karen J
- Finley, James E
- Hicks, Carol D
- Karmilowicz, Michael J
- Lanz, Thomas A
- Liston, Dane
- Liu, Xingrong
- Martin, Barbara-Anne
- Nelson, Robert B
- Nolan, Charles E
- Oborski, Christine E
- Parker, Christine P
- Richter, Karl E G
- Pozdnyakov, Nikolay
- Sahagan, Barbara G
- Schachter, Joel B
- Sokolowski, Sharon A
- Tate, Barbara
- Van Deusen, Jeffrey W
- Wood, Douglas E
- Wood, Kathleen M
Producer: 20110815
In:
Bioorganic & medicinal chemistry letters vol. 21
Availability: No items available.
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19.
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Design, synthesis, and in vivo characterization of a novel series of tetralin amino imidazoles as γ-secretase inhibitors: discovery of PF-3084014. [electronic resource] by
- Brodney, Michael A
- Auperin, David D
- Becker, Stacey L
- Bronk, Brian S
- Brown, Tracy M
- Coffman, Karen J
- Finley, James E
- Hicks, Carol D
- Karmilowicz, Michael J
- Lanz, Thomas A
- Liston, Dane
- Liu, Xingrong
- Martin, Barbara-Anne
- Nelson, Robert B
- Nolan, Charles E
- Oborski, Christine E
- Parker, Christine P
- Richter, Karl E G
- Pozdnyakov, Nikolay
- Sahagan, Barbara G
- Schachter, Joel B
- Sokolowski, Sharon A
- Tate, Barbara
- Wood, Douglas E
- Wood, Kathleen M
- Van Deusen, Jeffrey W
- Zhang, Lei
Producer: 20110815
In:
Bioorganic & medicinal chemistry letters vol. 21
Availability: No items available.
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20.
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Design and Synthesis of Clinical Candidate PF-06751979: A Potent, Brain Penetrant, β-Site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1) Inhibitor Lacking Hypopigmentation. [electronic resource] by
- O'Neill, Brian T
- Beck, Elizabeth M
- Butler, Christopher R
- Nolan, Charles E
- Gonzales, Cathleen
- Zhang, Lei
- Doran, Shawn D
- Lapham, Kimberly
- Buzon, Leanne M
- Dutra, Jason K
- Barreiro, Gabriela
- Hou, Xinjun
- Martinez-Alsina, Luis A
- Rogers, Bruce N
- Villalobos, Anabella
- Murray, John C
- Ogilvie, Kevin
- LaChapelle, Erik A
- Chang, Cheng
- Lanyon, Lorraine F
- Steppan, Claire M
- Robshaw, Ashley
- Hales, Katherine
- Boucher, Germaine G
- Pandher, Karamjeet
- Houle, Christopher
- Ambroise, Claude W
- Karanian, David
- Riddell, David
- Bales, Kelly R
- Brodney, Michael A
Producer: 20190603
In:
Journal of medicinal chemistry vol. 61
Availability: No items available.
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