Superoxide production by NAD(P)H oxidase and mitochondria is increased in genetically obese and hyperglycemic rat heart and aorta before the development of cardiac dysfunction. The role of glucose-6-phosphate dehydrogenase-derived NADPH. [electronic resource]
Producer: 20090812Description: H153-62 p. digitalISSN:- 1522-1539
- Animals
- Blood Glucose -- metabolism
- Diabetes Mellitus, Type 2 -- genetics
- Endothelium, Vascular -- physiopathology
- Fatty Acids, Nonesterified -- blood
- Gene Expression Regulation, Enzymologic -- genetics
- Glucosephosphate Dehydrogenase -- biosynthesis
- Glutathione -- metabolism
- Heart Diseases -- etiology
- Hydrogen Peroxide -- metabolism
- Hyperglycemia -- genetics
- Insulin -- blood
- Isometric Contraction -- physiology
- Mitochondria, Heart -- enzymology
- Myocardium -- enzymology
- NADP -- metabolism
- NADPH Oxidases -- metabolism
- Obesity -- genetics
- Rats
- Rats, Zucker
- Superoxides -- metabolism
- Triglycerides -- blood
- Up-Regulation
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
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