Inhibitory effects of Phyllanthus amarus and its major lignans on human microsomal cytochrome P450 activities: evidence for CYP3A4 mechanism-based inhibition. [electronic resource]
Producer: 20110930Description: 154-61 p. digitalISSN:- 1880-0920
- Aryl Hydrocarbon Hydroxylases -- antagonists & inhibitors
- Cytochrome P-450 CYP3A -- metabolism
- Cytochrome P-450 CYP3A Inhibitors
- Dose-Response Relationship, Drug
- Herb-Drug Interactions -- physiology
- Humans
- Inhibitory Concentration 50
- Ketoconazole -- pharmacology
- Lignans -- pharmacology
- Microsomes, Liver -- drug effects
- Phyllanthus -- metabolism
- Plant Extracts -- chemistry
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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