Antioxidants protect primary rat hepatocyte cultures against acetaminophen-induced DNA strand breaks but not against acetaminophen-induced cytotoxicity. [electronic resource]
Producer: 20031028Description: 179-87 p. digitalISSN:- 0300-483X
- Acetaminophen -- toxicity
- Acetylcysteine -- pharmacology
- Analgesics, Non-Narcotic -- toxicity
- Animals
- Antioxidants -- pharmacology
- Blotting, Northern
- Cell Death -- drug effects
- Chemical and Drug Induced Liver Injury
- Comet Assay
- DNA Damage
- Dose-Response Relationship, Drug
- Formazans -- metabolism
- Hepatocytes -- cytology
- Lipid Peroxides -- metabolism
- Liver Diseases -- genetics
- Male
- Neutral Red -- metabolism
- RNA -- chemistry
- Rats
- Rats, Wistar
- Silybin
- Silymarin -- pharmacology
- Tetrazolium Salts -- metabolism
- alpha-Tocopherol -- pharmacology
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Publication Type: Comparative Study; Journal Article
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