Combination simvastatin and metformin induces G1-phase cell cycle arrest and Ripk1- and Ripk3-dependent necrosis in C4-2B osseous metastatic castration-resistant prostate cancer cells. [electronic resource]
Producer: 20150702Description: e1536 p. digitalISSN:- 2041-4889
- Adaptor Proteins, Signal Transducing -- genetics
- Autophagy -- drug effects
- Cell Line, Tumor
- Chloroquine -- pharmacology
- Drug Combinations
- G1 Phase Cell Cycle Checkpoints -- drug effects
- Gene Expression Regulation, Neoplastic
- HMGB1 Protein -- genetics
- Humans
- Imidazoles -- pharmacology
- Indoles -- pharmacology
- Male
- Metformin -- pharmacology
- Microtubule-Associated Proteins -- genetics
- Necrosis -- genetics
- Prostate -- drug effects
- Prostatic Neoplasms, Castration-Resistant -- drug therapy
- RNA, Small Interfering -- genetics
- Receptor-Interacting Protein Serine-Threonine Kinases -- antagonists & inhibitors
- Sequestosome-1 Protein
- Signal Transduction
- Simvastatin -- pharmacology
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
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