The sclerostin-neutralizing antibody AbD09097 recognizes an epitope adjacent to sclerostin's binding site for the Wnt co-receptor LRP6. [electronic resource]
Producer: 20171121ISSN:- 2046-2441
- Animals
- Antibodies, Neutralizing -- chemistry
- Binding Sites
- Crystallography, X-Ray
- Epitopes -- metabolism
- Genetic Variation
- Humans
- Immunoglobulin Fab Fragments -- chemistry
- Low Density Lipoprotein Receptor-Related Protein-6 -- chemistry
- Mice
- Models, Molecular
- Peptide Library
- Protein Binding
- Proteins -- antagonists & inhibitors
- Structure-Activity Relationship
- Wnt Signaling Pathway
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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