A novel triazole, NMK-T-057, induces autophagic cell death in breast cancer cells by inhibiting γ-secretase-mediated activation of Notch signaling. [electronic resource]
Producer: 20200107Description: 6733-6750 p. digitalISSN:- 1083-351X
- Amyloid Precursor Protein Secretases -- antagonists & inhibitors
- Animals
- Apoptosis -- drug effects
- Autophagy -- drug effects
- Breast Neoplasms -- enzymology
- Carcinogenesis -- drug effects
- Cell Line, Tumor
- Down-Regulation -- drug effects
- Epithelial-Mesenchymal Transition -- drug effects
- Humans
- Mice
- Mice, Inbred BALB C
- Receptors, Notch -- metabolism
- Signal Transduction
- Triazoles -- pharmacology
- Xenograft Model Antitumor Assays
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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