Thermodynamics of binding of structurally similar ligands to histone deacetylase 8 sheds light on challenges in the rational design of potent and isozyme-selective inhibitors of the enzyme. [electronic resource]
Producer: 20150213Description: 7445-58 p. digitalISSN:- 1520-4995
- Calorimetry
- Catalytic Domain
- Drug Design
- Histone Deacetylase Inhibitors -- chemical synthesis
- Histone Deacetylases -- chemistry
- Humans
- Hydroxamic Acids -- chemical synthesis
- Isoenzymes -- antagonists & inhibitors
- Ligands
- Models, Molecular
- Molecular Structure
- Recombinant Proteins -- chemistry
- Repressor Proteins -- antagonists & inhibitors
- Static Electricity
- Thermodynamics
- Vorinostat
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
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