Inhibition of p70 S6 kinase activity by A77 1726 induces autophagy and enhances the degradation of superoxide dismutase 1 (SOD1) protein aggregates. [electronic resource]
Producer: 20191113Description: 407 p. digitalISSN:- 2041-4889
- AMP-Activated Protein Kinase Kinases
- Amino Acid Motifs
- Aniline Compounds -- pharmacology
- Animals
- Autophagy -- drug effects
- Autophagy-Related Protein 7 -- genetics
- Autophagy-Related Protein-1 Homolog -- genetics
- Cell Line
- Crotonates
- Hydroxybutyrates -- pharmacology
- MAP Kinase Kinase Kinases -- genetics
- Mice
- Nitriles
- Protein Aggregates -- drug effects
- Protein Kinases -- genetics
- Proteolysis -- drug effects
- Ribosomal Protein S6 Kinases, 70-kDa -- antagonists & inhibitors
- Superoxide Dismutase-1 -- genetics
- TOR Serine-Threonine Kinases -- genetics
- Toluidines
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
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