Pharmacological inhibitors of the mevalonate pathway activate pro-IL-1 processing and IL-1 release by human monocytes. [electronic resource]
Producer: 20110316Description: 112-20 p. digitalISSN:- 1952-4005
- Caspase 1 -- metabolism
- Cell Line
- Enzyme Activation -- drug effects
- Guanosine Triphosphate -- metabolism
- Humans
- Hydroxymethylglutaryl-CoA Reductase Inhibitors -- pharmacology
- Interleukin-1 -- metabolism
- Interleukin-1beta -- metabolism
- Lipopolysaccharides -- pharmacology
- Metabolic Networks and Pathways -- drug effects
- Mevalonic Acid -- metabolism
- Monocytes -- drug effects
- Phosphorylation -- drug effects
- Protein Precursors -- metabolism
- Protein Prenylation -- drug effects
- Protein Processing, Post-Translational -- drug effects
- Protein Transport -- drug effects
- Simvastatin -- pharmacology
- p38 Mitogen-Activated Protein Kinases -- metabolism
- rac1 GTP-Binding Protein -- metabolism
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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