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Pharmacokinetics and pharmacodynamics of multiple weekly subcutaneous efalizumab doses in patients with plaque psoriasis. [electronic resource] by
- Mortensen, Deborah L
- Walicke, Patricia A
- Wang, Xiaolin
- Kwon, Paul
- Kuebler, Peter
- Gottlieb, Alice B
- Krueger, James G
- Leonardi, Craig
- Miller, Bruce
- Joshi, Amita
Producer: 20060207
In:
Journal of clinical pharmacology vol. 45
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Discovery and SAR exploration of a novel series of imidazo[4,5-b]pyrazin-2-ones as potent and selective mTOR kinase inhibitors. [electronic resource] by
- Mortensen, Deborah S
- Perrin-Ninkovic, Sophie M
- Harris, Roy
- Lee, Branden G S
- Shevlin, Graziella
- Hickman, Matt
- Khambatta, Gody
- Bisonette, Rene R
- Fultz, Kimberly E
- Sankar, Sabita
Producer: 20120213
In:
Bioorganic & medicinal chemistry letters vol. 21
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Effect of antigen binding affinity and effector function on the pharmacokinetics and pharmacodynamics of anti-IgE monoclonal antibodies. [electronic resource] by
- Mortensen, Deborah L
- Prabhu, Saileta
- Stefanich, Eric G
- Kadkhodayan-Fischer, Saloumeh
- Gelzleichter, Thomas R
- Baker, Dana
- Jiang, Jenny
- Wallace, Kristin
- Iyer, Suhasini
- Fielder, Paul J
- Putnam, Wendy S
Producer: 20140113
In:
mAbs vol. 4
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Discovery of a Stress-Activated Protein Kinase Inhibitor for Lymphatic Filariasis. [electronic resource] by
- Tummalapalli, Sreedhar R
- Bhat, Rohit
- Chojnowski, Agnieszka
- Prorok, Monika
- Kreiss, Tamara
- Goldberg, Ronald
- Canan, Stacie
- Hawryluk, Natalie
- Mortensen, Deborah
- Khetani, Vikram
- Zeldis, Jerome
- Siekierka, John J
- Rotella, David P
Publication details: ACS medicinal chemistry letters Mar 2018
In:
ACS medicinal chemistry letters vol. 9
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Lead identification of a potent benzopyranone selective estrogen receptor modulator. [electronic resource] by
- McKie, Jeffrey A
- Bhagwat, Shripad S
- Brady, Helen
- Doubleday, Mary
- Gayo, Leah
- Hickman, Mathew
- Jalluri, Ravi K
- Khammungkhune, Sak
- Kois, Adam
- Mortensen, Deborah
- Richard, Normand
- Sapienza, John
- Shevlin, Graziella
- Stein, Bernd
- Sutherland, May
Producer: 20050202
In:
Bioorganic & medicinal chemistry letters vol. 14
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ABBY: A phase 2 randomized trial of crenezumab in mild to moderate Alzheimer disease. [electronic resource] by
- Cummings, Jeffrey L
- Cohen, Sharon
- van Dyck, Christopher H
- Brody, Mark
- Curtis, Craig
- Cho, William
- Ward, Michael
- Friesenhahn, Michel
- Rabe, Christina
- Brunstein, Flavia
- Quartino, Angelica
- Honigberg, Lee A
- Fuji, Reina N
- Clayton, David
- Mortensen, Deborah
- Ho, Carole
- Paul, Robert
Producer: 20190813
In:
Neurology vol. 90
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11.
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Amyloid positron emission tomography and cerebrospinal fluid results from a crenezumab anti-amyloid-beta antibody double-blind, placebo-controlled, randomized phase II study in mild-to-moderate Alzheimer's disease (BLAZE). [electronic resource] by
- Salloway, Stephen
- Honigberg, Lee A
- Cho, William
- Ward, Michael
- Friesenhahn, Michel
- Brunstein, Flavia
- Quartino, Angelica
- Clayton, David
- Mortensen, Deborah
- Bittner, Tobias
- Ho, Carole
- Rabe, Christina
- Schauer, Stephen P
- Wildsmith, Kristin R
- Fuji, Reina N
- Suliman, Shehnaaz
- Reiman, Eric M
- Chen, Kewei
- Paul, Robert
Producer: 20190909
In:
Alzheimer's research & therapy vol. 10
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Use of core modification in the discovery of CC214-2, an orally available, selective inhibitor of mTOR kinase. [electronic resource] by
- Mortensen, Deborah S
- Sapienza, John
- Lee, Branden G S
- Perrin-Ninkovic, Sophie M
- Harris, Roy
- Shevlin, Graziella
- Parnes, Jason S
- Whitefield, Brandon
- Hickman, Matt
- Khambatta, Gody
- Bisonette, Rene R
- Peng, Sophie
- Gamez, Jim C
- Leisten, Jim
- Narla, Rama Krishna
- Fultz, Kimberly E
- Sankar, Sabita
Producer: 20130903
In:
Bioorganic & medicinal chemistry letters vol. 23
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A phase I dose-escalation study to assess safety, tolerability, pharmacokinetics, and preliminary efficacy of the dual mTORC1/mTORC2 kinase inhibitor CC-223 in patients with advanced solid tumors or multiple myeloma. [electronic resource] by
- Bendell, Johanna C
- Kelley, Robin K
- Shih, Kent C
- Grabowsky, Jennifer A
- Bergsland, Emily
- Jones, Suzanne
- Martin, Thomas
- Infante, Jeffrey R
- Mischel, Paul S
- Matsutani, Tomoo
- Xu, Shuichan
- Wong, Lilly
- Liu, Yong
- Wu, Xiaoling
- Mortensen, Deborah S
- Chopra, Rajesh
- Hege, Kristen
- Munster, Pamela N
Producer: 20160201
In:
Cancer vol. 121
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An effector-reduced anti-β-amyloid (Aβ) antibody with unique aβ binding properties promotes neuroprotection and glial engulfment of Aβ. [electronic resource] by
- Adolfsson, Oskar
- Pihlgren, Maria
- Toni, Nicolas
- Varisco, Yvan
- Buccarello, Anna Lucia
- Antoniello, Katia
- Lohmann, Sophie
- Piorkowska, Kasia
- Gafner, Valerie
- Atwal, Jasvinder K
- Maloney, Janice
- Chen, Mark
- Gogineni, Alvin
- Weimer, Robby M
- Mortensen, Deborah L
- Friesenhahn, Michel
- Ho, Carole
- Paul, Robert
- Pfeifer, Andrea
- Muhs, Andreas
- Watts, Ryan J
Producer: 20120924
In:
The Journal of neuroscience : the official journal of the Society for Neuroscience vol. 32
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A therapeutic antibody targeting BACE1 inhibits amyloid-β production in vivo. [electronic resource] by
- Atwal, Jasvinder K
- Chen, Yongmei
- Chiu, Cecilia
- Mortensen, Deborah L
- Meilandt, William J
- Liu, Yichin
- Heise, Christopher E
- Hoyte, Kwame
- Luk, Wilman
- Lu, Yanmei
- Peng, Kun
- Wu, Ping
- Rouge, Lionel
- Zhang, Yingnan
- Lazarus, Robert A
- Scearce-Levie, Kimberly
- Wang, Weiru
- Wu, Yan
- Tessier-Lavigne, Marc
- Watts, Ryan J
Producer: 20111216
In:
Science translational medicine vol. 3
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CC-223, a Potent and Selective Inhibitor of mTOR Kinase: In Vitro and In Vivo Characterization. [electronic resource] by
- Mortensen, Deborah S
- Fultz, Kimberly E
- Xu, Shuichan
- Xu, Weiming
- Packard, Garrick
- Khambatta, Godrej
- Gamez, James C
- Leisten, Jim
- Zhao, Jingjing
- Apuy, Julius
- Ghoreishi, Kamran
- Hickman, Matt
- Narla, Rama Krishna
- Bissonette, Rene
- Richardson, Samantha
- Peng, Sophie X
- Perrin-Ninkovic, Sophie
- Tran, Tam
- Shi, Tao
- Yang, Wen Qing
- Tong, Zeen
- Cathers, Brian E
- Moghaddam, Mehran F
- Canan, Stacie S
- Worland, Peter
- Sankar, Sabita
- Raymon, Heather K
Producer: 20160412
In:
Molecular cancer therapeutics vol. 14
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The mTOR kinase inhibitors, CC214-1 and CC214-2, preferentially block the growth of EGFRvIII-activated glioblastomas. [electronic resource] by
- Gini, Beatrice
- Zanca, Ciro
- Guo, Deliang
- Matsutani, Tomoo
- Masui, Kenta
- Ikegami, Shiro
- Yang, Huijun
- Nathanson, David
- Villa, Genaro R
- Shackelford, David
- Zhu, Shaojun
- Tanaka, Kazuhiro
- Babic, Ivan
- Akhavan, David
- Lin, Kelly
- Assuncao, Alvaro
- Gu, Yuchao
- Bonetti, Bruno
- Mortensen, Deborah S
- Xu, Shuichan
- Raymon, Heather K
- Cavenee, Webster K
- Furnari, Frank B
- James, C David
- Kroemer, Guido
- Heath, James R
- Hege, Kristen
- Chopra, Rajesh
- Cloughesy, Timothy F
- Mischel, Paul S
Producer: 20140519
In:
Clinical cancer research : an official journal of the American Association for Cancer Research vol. 19
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Optimization of a Series of Triazole Containing Mammalian Target of Rapamycin (mTOR) Kinase Inhibitors and the Discovery of CC-115. [electronic resource] by
- Mortensen, Deborah S
- Perrin-Ninkovic, Sophie M
- Shevlin, Graziella
- Elsner, Jan
- Zhao, Jingjing
- Whitefield, Brandon
- Tehrani, Lida
- Sapienza, John
- Riggs, Jennifer R
- Parnes, Jason S
- Papa, Patrick
- Packard, Garrick
- Lee, Branden G S
- Harris, Roy
- Correa, Matthew
- Bahmanyar, Sogole
- Richardson, Samantha J
- Peng, Sophie X
- Leisten, Jim
- Khambatta, Godrej
- Hickman, Matt
- Gamez, James C
- Bisonette, René R
- Apuy, Julius
- Cathers, Brian E
- Canan, Stacie S
- Moghaddam, Mehran F
- Raymon, Heather K
- Worland, Peter
- Narla, Rama Krishna
- Fultz, Kimberly E
- Sankar, Sabita
Producer: 20151012
In:
Journal of medicinal chemistry vol. 58
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19.
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Discovery of mammalian target of rapamycin (mTOR) kinase inhibitor CC-223. [electronic resource] by
- Mortensen, Deborah S
- Perrin-Ninkovic, Sophie M
- Shevlin, Graziella
- Zhao, Jingjing
- Packard, Garrick
- Bahmanyar, Sogole
- Correa, Matthew
- Elsner, Jan
- Harris, Roy
- Lee, Branden G S
- Papa, Patrick
- Parnes, Jason S
- Riggs, Jennifer R
- Sapienza, John
- Tehrani, Lida
- Whitefield, Brandon
- Apuy, Julius
- Bisonette, René R
- Gamez, James C
- Hickman, Matt
- Khambatta, Godrej
- Leisten, Jim
- Peng, Sophie X
- Richardson, Samantha J
- Cathers, Brian E
- Canan, Stacie S
- Moghaddam, Mehran F
- Raymon, Heather K
- Worland, Peter
- Narla, Rama Krishna
- Fultz, Kimberly E
- Sankar, Sabita
Producer: 20151002
In:
Journal of medicinal chemistry vol. 58
Availability: No items available.
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