Coronarin D, a labdane diterpene, inhibits both constitutive and inducible nuclear factor-kappa B pathway activation, leading to potentiation of apoptosis, inhibition of invasion, and suppression of osteoclastogenesis. [electronic resource]
Producer: 20081112Description: 3306-17 p. digitalISSN:- 1535-7163
- Animals
- Antineoplastic Agents -- chemistry
- Apoptosis -- drug effects
- Cell Differentiation -- drug effects
- Cell Line, Tumor
- Cell Nucleus -- drug effects
- Diterpenes -- chemistry
- Gene Expression Regulation, Neoplastic -- drug effects
- Genes, Reporter
- Humans
- I-kappa B Proteins -- metabolism
- Mice
- NF-KappaB Inhibitor alpha
- NF-kappa B -- metabolism
- Neoplasm Invasiveness
- Neoplasm Metastasis
- Neoplasm Proteins -- metabolism
- Osteoclasts -- cytology
- Phosphorylation -- drug effects
- Protein Processing, Post-Translational -- drug effects
- Protein Transport -- drug effects
- RANK Ligand -- pharmacology
- Transcription Factor RelA -- metabolism
- Tumor Necrosis Factor-alpha -- pharmacology
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Publication Type: Journal Article; Retracted Publication
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