Lysosomal protein thermal stability does not correlate with cellular half-life: global observations and a case study of tripeptidyl-peptidase 1. [electronic resource]
Producer: 20200730Description: 727-745 p. digitalISSN:- 1470-8728
- Aminopeptidases -- chemistry
- Animals
- CHO Cells
- Cloning, Molecular
- Cricetulus
- Dipeptidyl-Peptidases and Tripeptidyl-Peptidases -- chemistry
- Endopeptidases -- chemistry
- Enzyme Replacement Therapy
- Enzyme Stability
- Humans
- Lymphocytes
- Mutation
- Neuronal Ceroid-Lipofuscinoses -- drug therapy
- Primary Cell Culture
- Protein Engineering -- methods
- Proteins -- chemistry
- Serine Proteases -- chemistry
- Tripeptidyl-Peptidase 1
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Publication Type: Journal Article; Research Support, N.I.H., Extramural
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