Mitochondrial energetic and AKT status mediate metabolic effects and apoptosis of metformin in human leukemic cells. [electronic resource]
Producer: 20140109Description: 2129-38 p. digitalISSN:- 1476-5551
- AMP-Activated Protein Kinases -- antagonists & inhibitors
- Adenosine Triphosphate -- metabolism
- Animals
- Apoptosis -- drug effects
- Blotting, Western
- Cell Proliferation -- drug effects
- Chromatography, Liquid
- Glucose -- metabolism
- Glycolysis -- drug effects
- Humans
- Hypoglycemic Agents -- pharmacology
- Immunoenzyme Techniques
- Lactic Acid -- metabolism
- Leukemia -- drug therapy
- Metformin -- pharmacology
- Mice
- Mice, Nude
- Mitochondria -- drug effects
- Oxygen Consumption -- drug effects
- Phosphorylation -- drug effects
- Proto-Oncogene Proteins c-akt -- metabolism
- RNA, Small Interfering -- genetics
- Spectrometry, Mass, Electrospray Ionization
- Tumor Cells, Cultured
- Xenograft Model Antitumor Assays
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
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