The alpha-subunit of the epithelial sodium channel is an aldosterone-induced transcript in mammalian collecting ducts, and this transcriptional response is mediated via distinct cis-elements in the 5'-flanking region of the gene. [electronic resource]
Producer: 20010920Description: 575-88 p. digitalISSN:- 0888-8809
- Aldosterone -- metabolism
- Animals
- Base Sequence
- Binding Sites
- Cells, Cultured
- Cloning, Molecular
- Dactinomycin -- pharmacology
- Dexamethasone -- pharmacology
- Dogs
- Epithelial Sodium Channels
- Gonanes -- pharmacology
- Humans
- Kidney Tubules, Collecting -- cytology
- Mice
- Mifepristone -- pharmacology
- Molecular Sequence Data
- Promoter Regions, Genetic
- Protein Subunits
- Receptors, Glucocorticoid -- antagonists & inhibitors
- Receptors, Mineralocorticoid -- drug effects
- Regulatory Sequences, Nucleic Acid
- Response Elements
- Sodium Channels -- genetics
- Transcription, Genetic
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
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