Prediction and Quantification of Hepatic Transporter-Mediated Uptake of Pitavastatin Utilizing a Combination of the Relative Activity Factor Approach and Mechanistic Modeling. [electronic resource]
Producer: 20181113Description: 953-963 p. digitalISSN:- 1521-009X
- Adult
- Biological Transport -- physiology
- Cell Line
- Cyclosporine -- metabolism
- Drug Interactions -- physiology
- Female
- HEK293 Cells
- Hepatocytes -- drug effects
- Humans
- Hydroxymethylglutaryl-CoA Reductase Inhibitors -- metabolism
- Liver -- drug effects
- Liver-Specific Organic Anion Transporter 1 -- metabolism
- Male
- Membrane Transport Proteins -- metabolism
- Middle Aged
- Organic Anion Transporters, Sodium-Dependent -- metabolism
- Quinolines -- metabolism
- Rifampin -- metabolism
- Solute Carrier Organic Anion Transporter Family Member 1B3 -- metabolism
- Symporters -- metabolism
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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