Discovery of potent inhibitors of dihydroneopterin aldolase using CrystaLEAD high-throughput X-ray crystallographic screening and structure-directed lead optimization. [electronic resource]
Producer: 20040510Description: 1709-18 p. digitalISSN:- 0022-2623
- Aldehyde-Lyases -- antagonists & inhibitors
- Benzoates -- chemical synthesis
- Binding Sites
- Crystallography, X-Ray
- Databases, Factual
- Enzyme Inhibitors -- chemical synthesis
- Guanine -- analogs & derivatives
- Models, Molecular
- Molecular Structure
- Neopterin -- chemistry
- Purines -- chemistry
- Pyrimidines -- chemical synthesis
- Structure-Activity Relationship
- Triazoles -- chemical synthesis
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Publication Type: Journal Article
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