RasGRP1 overexpression in T-ALL increases basal nucleotide exchange on Ras rendering the Ras/PI3K/Akt pathway responsive to protumorigenic cytokines. [electronic resource]
Producer: 20170913Description: 3658-68 p. digitalISSN:- 1476-5594
- Animals
- Blotting, Western
- Cell Line, Tumor
- Child
- Cytokines -- pharmacology
- DNA-Binding Proteins -- metabolism
- Diglycerides -- metabolism
- Guanine Nucleotide Exchange Factors -- metabolism
- Guanosine Diphosphate -- metabolism
- Guanosine Triphosphate -- metabolism
- Humans
- Interleukin-2 -- pharmacology
- Interleukin-7 -- pharmacology
- Interleukin-9 -- pharmacology
- Mice
- Phosphatidylinositol 3-Kinases -- metabolism
- Phospholipase C gamma -- metabolism
- Precursor T-Cell Lymphoblastic Leukemia-Lymphoma -- genetics
- Proto-Oncogene Proteins c-akt -- metabolism
- Receptors, Cytokine -- metabolism
- Signal Transduction -- drug effects
- ras Proteins -- metabolism
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Publication Type: Journal Article; Research Support, N.I.H., Extramural
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