A virus-directed enzyme prodrug therapy approach to purging neuroblastoma cells from hematopoietic cells using adenovirus encoding rabbit carboxylesterase and CPT-11. [electronic resource]
Producer: 20010719Description: 5083-9 p. digitalISSN:- 0008-5472
- Adenoviridae -- genetics
- Antigens, CD34 -- biosynthesis
- Antineoplastic Agents, Phytogenic -- pharmacokinetics
- Biomarkers, Tumor -- genetics
- Biotransformation
- Bone Marrow Purging -- methods
- Camptothecin -- analogs & derivatives
- Carboxylesterase
- Carboxylic Ester Hydrolases -- genetics
- DNA, Complementary -- genetics
- Genetic Therapy
- Genetic Vectors -- genetics
- Hematopoietic Stem Cells -- immunology
- Humans
- Irinotecan
- Leukocytes, Mononuclear -- virology
- Neuroblastoma -- genetics
- Prodrugs -- pharmacokinetics
- Reverse Transcriptase Polymerase Chain Reaction
- Transduction, Genetic
- Tumor Cells, Cultured
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
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