Selective chemical probe inhibitor of Stat3, identified through structure-based virtual screening, induces antitumor activity. [electronic resource]
Producer: 20070620Description: 7391-6 p. digitalISSN:- 0027-8424
- Aminosalicylic Acid -- chemistry
- Aminosalicylic Acids
- Animals
- Antineoplastic Agents -- chemistry
- Apoptosis
- Benzenesulfonates -- chemistry
- Cell Line
- Computational Biology
- DNA -- chemistry
- Drug Evaluation, Preclinical
- Gene Expression Regulation
- Humans
- Mice
- Models, Molecular
- Neoplasms -- drug therapy
- Phosphotyrosine -- metabolism
- Protein Binding
- Protein Structure, Tertiary
- STAT3 Transcription Factor -- antagonists & inhibitors
- Transcription, Genetic -- genetics
- Xenograft Model Antitumor Assays
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Publication Type: Journal Article; Research Support, N.I.H., Extramural
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