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A potent mechanism-inspired O-GlcNAcase inhibitor that blocks phosphorylation of tau in vivo. [electronic resource] by
- Yuzwa, Scott A
- Macauley, Matthew S
- Heinonen, Julia E
- Shan, Xiaoyang
- Dennis, Rebecca J
- He, Yuan
- Whitworth, Garrett E
- Stubbs, Keith A
- McEachern, Ernest J
- Davies, Gideon J
- Vocadlo, David J
Producer: 20080813
In:
Nature chemical biology vol. 4
Availability: No items available.
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6.
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Pharmacological inhibition of O-GlcNAcase (OGA) prevents cognitive decline and amyloid plaque formation in bigenic tau/APP mutant mice. [electronic resource] by
- Yuzwa, Scott A
- Shan, Xiaoyang
- Jones, Bryan A
- Zhao, Gang
- Woodward, Melissa L
- Li, Xiaojing
- Zhu, Yanping
- McEachern, Ernest J
- Silverman, Michael A
- Watson, Neil V
- Gong, Cheng-Xin
- Vocadlo, David J
Producer: 20150330
In:
Molecular neurodegeneration vol. 9
Availability: No items available.
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7.
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Discovery of novel small molecule orally bioavailable C-X-C chemokine receptor 4 antagonists that are potent inhibitors of T-tropic (X4) HIV-1 replication. [electronic resource] by
- Skerlj, Renato T
- Bridger, Gary J
- Kaller, Al
- McEachern, Ernest J
- Crawford, Jason B
- Zhou, Yuanxi
- Atsma, Bem
- Langille, Jonathon
- Nan, Susan
- Veale, Duane
- Wilson, Trevor
- Harwig, Curtis
- Hatse, Sigrid
- Princen, Katrien
- De Clercq, Erik
- Schols, Dominique
Producer: 20100514
In:
Journal of medicinal chemistry vol. 53
Availability: No items available.
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8.
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Design of novel CXCR4 antagonists that are potent inhibitors of T-tropic (X4) HIV-1 replication. [electronic resource] by
- Skerlj, Renato
- Bridger, Gary
- McEachern, Ernest
- Harwig, Curtis
- Smith, Chris
- Kaller, Alan
- Veale, Duane
- Yee, Helen
- Skupinska, Krystyna
- Wauthy, Rossana
- Wang, Letian
- Baird, Ian
- Zhu, Yongbao
- Burrage, Kate
- Yang, Wen
- Sartori, Michael
- Huskens, Dana
- De Clercq, Erik
- Schols, Dominique
Producer: 20110614
In:
Bioorganic & medicinal chemistry letters vol. 21
Availability: No items available.
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9.
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Mitigating hERG Inhibition: Design of Orally Bioavailable CCR5 Antagonists as Potent Inhibitors of R5 HIV-1 Replication. [electronic resource] by
- Skerlj, Renato
- Bridger, Gary
- Zhou, Yuanxi
- Bourque, Elyse
- McEachern, Ernest
- Danthi, Sanjay
- Langille, Jonathan
- Harwig, Curtis
- Veale, Duane
- Carpenter, Bryon
- Ba, Tuya
- Bey, Michael
- Baird, Ian
- Wilson, Trevor
- Metz, Markus
- MacFarland, Ron
- Mosi, Renee
- Bodart, Veronique
- Wong, Rebecca
- Fricker, Simon
- Huskens, Dana
- Schols, Dominique
Producer: 20140605
In:
ACS medicinal chemistry letters vol. 3
Availability: No items available.
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10.
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Design and synthesis of pyridin-2-ylmethylaminopiperidin-1-ylbutyl amide CCR5 antagonists that are potent inhibitors of M-tropic (R5) HIV-1 replication. [electronic resource] by
- Skerlj, Renato
- Bridger, Gary
- Zhou, Yuanxi
- Bourque, Elyse
- McEachern, Ernest
- Langille, Jonathan
- Harwig, Curtis
- Veale, Duane
- Yang, Wen
- Li, Tongshong
- Zhu, Yongbao
- Bey, Michael
- Baird, Ian
- Sartori, Michael
- Metz, Markus
- Mosi, Renee
- Nelson, Kim
- Bodart, Veronique
- Wong, Rebecca
- Fricker, Simon
- Mac Farland, Ron
- Huskens, Dana
- Schols, Dominique
Producer: 20120418
In:
Bioorganic & medicinal chemistry letters vol. 21
Availability: No items available.
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11.
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Discovery of MK-8719, a Potent O-GlcNAcase Inhibitor as a Potential Treatment for Tauopathies. [electronic resource] by
- Selnick, Harold G
- Hess, J Fred
- Tang, Cuyue
- Liu, Kun
- Schachter, Joel B
- Ballard, Jeanine E
- Marcus, Jacob
- Klein, Daniel J
- Wang, Xiaohai
- Pearson, Michelle
- Savage, Mary J
- Kaul, Ramesh
- Li, Tong-Shuang
- Vocadlo, David J
- Zhou, Yuanxi
- Zhu, Yongbao
- Mu, Changwei
- Wang, Yaode
- Wei, Zhongyong
- Bai, Chang
- Duffy, Joseph L
- McEachern, Ernest J
Producer: 20200714
In:
Journal of medicinal chemistry vol. 62
Availability: No items available.
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12.
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Inhibition of O-GlcNAcase leads to elevation of O-GlcNAc tau and reduction of tauopathy and cerebrospinal fluid tau in rTg4510 mice. [electronic resource] by
- Hastings, Nicholas B
- Wang, Xiaohai
- Song, Lixin
- Butts, Brent D
- Grotz, Diane
- Hargreaves, Richard
- Fred Hess, J
- Hong, Kwok-Lam Karen
- Huang, Cathy Ruey-Ruey
- Hyde, Lynn
- Laverty, Maureen
- Lee, Julie
- Levitan, Diane
- Lu, Sherry X
- Maguire, Maureen
- Mahadomrongkul, Veeravan
- McEachern, Ernest J
- Ouyang, Xuesong
- Rosahl, Thomas W
- Selnick, Harold
- Stanton, Michaela
- Terracina, Giuseppe
- Vocadlo, David J
- Wang, Ganfeng
- Duffy, Joseph L
- Parker, Eric M
- Zhang, Lili
Producer: 20180326
In:
Molecular neurodegeneration vol. 12
Availability: No items available.
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13.
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Design of substituted imidazolidinylpiperidinylbenzoic acids as chemokine receptor 5 antagonists: potent inhibitors of R5 HIV-1 replication. [electronic resource] by
- Skerlj, Renato
- Bridger, Gary
- Zhou, Yuanxi
- Bourque, Elyse
- McEachern, Ernest
- Metz, Markus
- Harwig, Curtis
- Li, Tong-Shuang
- Yang, Wen
- Bogucki, David
- Zhu, Yongbao
- Langille, Jonathan
- Veale, Duane
- Ba, Tuya
- Bey, Michael
- Baird, Ian
- Kaller, Alan
- Krumpak, Maria
- Leitch, David
- Satori, Michael
- Vocadlo, Krystyna
- Guay, Danielle
- Nan, Susan
- Yee, Helen
- Crawford, Jason
- Chen, Gang
- Wilson, Trevor
- Carpenter, Bryon
- Gauthier, David
- Macfarland, Ron
- Mosi, Renee
- Bodart, Veronique
- Wong, Rebecca
- Fricker, Simon
- Schols, Dominique
Producer: 20140310
In:
Journal of medicinal chemistry vol. 56
Availability: No items available.
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