A Common Type 2 Diabetes Risk Variant Potentiates Activity of an Evolutionarily Conserved Islet Stretch Enhancer and Increases C2CD4A and C2CD4B Expression. [electronic resource]
Producer: 20181211Description: 620-635 p. digitalISSN:- 1537-6605
- Aged
- Alleles
- Animals
- Base Sequence
- Calcium-Binding Proteins -- genetics
- Cell Line
- Chromatin -- metabolism
- Chromosomes, Human, Pair 15 -- genetics
- Conserved Sequence
- Cytokines -- metabolism
- DNA, Intergenic -- genetics
- Enhancer Elements, Genetic -- genetics
- Evolution, Molecular
- Humans
- Inflammation Mediators -- metabolism
- Islets of Langerhans -- pathology
- Mice
- Middle Aged
- Mutation -- genetics
- NFATC Transcription Factors -- metabolism
- Nuclear Proteins -- genetics
- Physical Chromosome Mapping
- Polymorphism, Single Nucleotide -- genetics
- Proinsulin -- metabolism
- Rats
- Risk Factors
- Transcription Factors -- genetics
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't
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