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Synthesis of a novel C2/C2'-aryl-substituted pyrrolo[2,1-c][1,4]benzodiazepine dimer prodrug with improved water solubility and reduced DNA reaction rate. [electronic resource] by
- Howard, Philip W
- Chen, Zhizhi
- Gregson, Stephen J
- Masterson, Luke A
- Tiberghien, Arnaud C
- Cooper, Nectaroula
- Fang, Min
- Coffils, Marissa J
- Klee, Sarah
- Hartley, John A
- Thurston, David E
Producer: 20100127
In:
Bioorganic & medicinal chemistry letters vol. 19
Availability: No items available.
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Synthesis and evaluation of pyrrolobenzodiazepine dimer antibody-drug conjugates with dual β-glucuronide and dipeptide triggers. [electronic resource] by
- Gregson, Stephen J
- Barrett, Allison M
- Patel, Neki V
- Kang, Gyoung-Dong
- Schiavone, Davide
- Sult, Erin
- Barry, Conor S
- Vijayakrishnan, Balakumar
- Adams, Lauren R
- Masterson, Luke A
- D'Hooge, Francois
- Snaith, Mike
- Harper, Jay
- Hartley, John A
- Howard, Philip W
Producer: 20191104
In:
European journal of medicinal chemistry vol. 179
Availability: No items available.
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6.
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SG2285, a novel C2-aryl-substituted pyrrolobenzodiazepine dimer prodrug that cross-links DNA and exerts highly potent antitumor activity. [electronic resource] by
- Hartley, John A
- Hamaguchi, Anzu
- Coffils, Marissa
- Martin, Christopher R H
- Suggitt, Marie
- Chen, Zhizhi
- Gregson, Stephen J
- Masterson, Luke A
- Tiberghien, Arnaud C
- Hartley, Janet M
- Pepper, Christopher
- Lin, Thet Thet
- Fegan, Christopher
- Thurston, David E
- Howard, Philip W
Producer: 20101007
In:
Cancer research vol. 70
Availability: No items available.
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Design, synthesis, and biophysical and biological evaluation of a series of pyrrolobenzodiazepine-poly(N-methylpyrrole) conjugates. [electronic resource] by
- Wells, Geoff
- Martin, Christopher R H
- Howard, Philip W
- Sands, Zara A
- Laughton, Charles A
- Tiberghien, Arnaud
- Woo, Chi Kit
- Masterson, Luke A
- Stephenson, Marissa J
- Hartley, John A
- Jenkins, Terence C
- Shnyder, Steven D
- Loadman, Paul M
- Waring, Michael J
- Thurston, David E
Producer: 20061016
In:
Journal of medicinal chemistry vol. 49
Availability: No items available.
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8.
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Pre-clinical pharmacology and mechanism of action of SG3199, the pyrrolobenzodiazepine (PBD) dimer warhead component of antibody-drug conjugate (ADC) payload tesirine. [electronic resource] by
- Hartley, John A
- Flynn, Michael J
- Bingham, John P
- Corbett, Simon
- Reinert, Halla
- Tiberghien, Arnaud
- Masterson, Luke A
- Antonow, Dyeison
- Adams, Lauren
- Chowdhury, Sajidah
- Williams, David G
- Mao, Shenlan
- Harper, Jay
- Havenith, Carin E G
- Zammarchi, Francesca
- Chivers, Simon
- van Berkel, Patrick H
- Howard, Philip W
Producer: 20191025
In:
Scientific reports vol. 8
Availability: No items available.
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9.
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ADCT-301, a Pyrrolobenzodiazepine (PBD) Dimer-Containing Antibody-Drug Conjugate (ADC) Targeting CD25-Expressing Hematological Malignancies. [electronic resource] by
- Flynn, Michael J
- Zammarchi, Francesca
- Tyrer, Peter C
- Akarca, Ayse U
- Janghra, Narinder
- Britten, Charles E
- Havenith, Carin E G
- Levy, Jean-Noel
- Tiberghien, Arnaud
- Masterson, Luke A
- Barry, Conor
- D'Hooge, Francois
- Marafioti, Teresa
- Parren, Paul W H I
- Williams, David G
- Howard, Philip W
- van Berkel, Patrick H
- Hartley, John A
Producer: 20170615
In:
Molecular cancer therapeutics vol. 15
Availability: No items available.
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10.
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Pyrrolobenzodiazepine Dimer Antibody-Drug Conjugates: Synthesis and Evaluation of Noncleavable Drug-Linkers. [electronic resource] by
- Gregson, Stephen J
- Masterson, Luke A
- Wei, Binqing
- Pillow, Thomas H
- Spencer, Susan D
- Kang, Gyoung-Dong
- Yu, Shang-Fan
- Raab, Helga
- Lau, Jeffrey
- Li, Guangmin
- Lewis Phillips, Gail D
- Gunzner-Toste, Janet
- Safina, Brian S
- Ohri, Rachana
- Darwish, Martine
- Kozak, Katherine R
- Dela Cruz-Chuh, Josefa
- Polson, Andrew
- Flygare, John A
- Howard, Philip W
Producer: 20171229
In:
Journal of medicinal chemistry vol. 60
Availability: No items available.
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11.
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Discovery of Peptidomimetic Antibody-Drug Conjugate Linkers with Enhanced Protease Specificity. [electronic resource] by
- Wei, BinQing
- Gunzner-Toste, Janet
- Yao, Hui
- Wang, Tao
- Wang, Jing
- Xu, Zijin
- Chen, Jinhua
- Wai, John
- Nonomiya, Jim
- Tsai, Siao Ping
- Chuh, Josefa
- Kozak, Katherine R
- Liu, Yichin
- Yu, Shang-Fan
- Lau, Jeff
- Li, Guangmin
- Phillips, Gail D
- Leipold, Doug
- Kamath, Amrita
- Su, Dian
- Xu, Keyang
- Eigenbrot, Charles
- Steinbacher, Stefan
- Ohri, Rachana
- Raab, Helga
- Staben, Leanna R
- Zhao, Guiling
- Flygare, John A
- Pillow, Thomas H
- Verma, Vishal
- Masterson, Luke A
- Howard, Philip W
- Safina, Brian
Producer: 20190218
In:
Journal of medicinal chemistry vol. 61
Availability: No items available.
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