DNA repair contributes to the drug-resistant phenotype of primary acute myeloid leukaemia cells with FLT3 internal tandem duplications and is reversed by the FLT3 inhibitor PKC412. [electronic resource]
Producer: 20070920Description: 2130-6 p. digitalISSN:- 0887-6924
- DNA Repair
- Drug Resistance, Neoplasm
- Etoposide -- pharmacology
- HL-60 Cells
- Humans
- Leukemia, Myeloid, Acute -- drug therapy
- Phenotype
- Phosphorylation
- Protein Kinase Inhibitors -- pharmacology
- RNA, Small Interfering -- pharmacology
- Rad51 Recombinase -- genetics
- STAT5 Transcription Factor -- metabolism
- Staurosporine -- analogs & derivatives
- Tandem Repeat Sequences
- fms-Like Tyrosine Kinase 3 -- antagonists & inhibitors
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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