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Structural basis for isoform selectivity in a class of benzothiazole inhibitors of phosphoinositide 3-kinase γ. [electronic resource] by
- Collier, Philip N
- Martinez-Botella, Gabriel
- Cornebise, Mark
- Cottrell, Kevin M
- Doran, John D
- Griffith, James P
- Mahajan, Sudipta
- Maltais, François
- Moody, Cameron S
- Huck, Emilie Porter
- Wang, Tiansheng
- Aronov, Alex M
Producer: 20150427
In:
Journal of medicinal chemistry vol. 58
Availability: No items available.
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5.
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Antibacterial inhibitors of Gram-positive thymidylate kinase: structure-activity relationships and chiral preference of a new hydrophobic binding region. [electronic resource] by
- Kawatkar, Sameer P
- Keating, Thomas A
- Olivier, Nelson B
- Breen, John N
- Green, Oluyinka M
- Guler, Satenig Y
- Hentemann, Martin F
- Loch, James T
- McKenzie, Andrew R
- Newman, Joseph V
- Otterson, Linda G
- Martínez-Botella, Gabriel
Producer: 20140820
In:
Journal of medicinal chemistry vol. 57
Availability: No items available.
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6.
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Neuroactive Steroids. 1. Positive Allosteric Modulators of the (γ-Aminobutyric Acid)A Receptor: Structure-Activity Relationships of Heterocyclic Substitution at C-21. [electronic resource] by
- Martinez Botella, Gabriel
- Salituro, Francesco G
- Harrison, Boyd L
- Beresis, Richard T
- Bai, Zhu
- Shen, Kaisheng
- Belfort, Gabriel M
- Loya, Carlos M
- Ackley, Michael A
- Grossman, Scott J
- Hoffmann, Ethan
- Jia, Shiling
- Wang, Jiamiao
- Doherty, James J
- Robichaud, Albert J
Producer: 20150629
In:
Journal of medicinal chemistry vol. 58
Availability: No items available.
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7.
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Neuroactive Steroid [electronic resource] by
- La, Daniel S
- Salituro, Francesco G
- Martinez Botella, Gabriel
- Griffin, Andrew M
- Bai, Zhu
- Ackley, Michael A
- Dai, Jing
- Doherty, James J
- Harrison, Boyd L
- Hoffmann, Ethan C
- Kazdoba, Tatiana M
- Lewis, Michael C
- Quirk, Michael C
- Robichaud, Albert J
Producer: 20200622
In:
Journal of medicinal chemistry vol. 62
Availability: No items available.
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8.
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Neuroactive Steroids. 2. 3α-Hydroxy-3β-methyl-21-(4-cyano-1H-pyrazol-1'-yl)-19-nor-5β-pregnan-20-one (SAGE-217): A Clinical Next Generation Neuroactive Steroid Positive Allosteric Modulator of the (γ-Aminobutyric Acid) [electronic resource] by
- Martinez Botella, Gabriel
- Salituro, Francesco G
- Harrison, Boyd L
- Beresis, Richard T
- Bai, Zhu
- Blanco, Maria-Jesus
- Belfort, Gabriel M
- Dai, Jing
- Loya, Carlos M
- Ackley, Michael A
- Althaus, Alison L
- Grossman, Scott J
- Hoffmann, Ethan
- Doherty, James J
- Robichaud, Albert J
Producer: 20171016
In:
Journal of medicinal chemistry vol. 60
Availability: No items available.
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9.
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Flipped out: structure-guided design of selective pyrazolylpyrrole ERK inhibitors. [electronic resource] by
- Aronov, Alex M
- Baker, Christopher
- Bemis, Guy W
- Cao, Jingrong
- Chen, Guanjing
- Ford, Pamella J
- Germann, Ursula A
- Green, Jeremy
- Hale, Michael R
- Jacobs, Marc
- Janetka, James W
- Maltais, Francois
- Martinez-Botella, Gabriel
- Namchuk, Mark N
- Straub, Judy
- Tang, Qing
- Xie, Xiaoling
Producer: 20070427
In:
Journal of medicinal chemistry vol. 50
Availability: No items available.
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10.
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Negishi cross-coupling enabled synthesis of novel NAD(+)-dependent DNA ligase inhibitors and SAR development. [electronic resource] by
- Murphy-Benenato, Kerry E
- Gingipalli, Lakshmaiah
- Boriack-Sjodin, P Ann
- Martinez-Botella, Gabriel
- Carcanague, Dan
- Eyermann, Charles J
- Gowravaram, Madhu
- Harang, Jenna
- Hale, Michael R
- Ioannidis, Georgine
- Jahic, Harris
- Johnstone, Michele
- Kutschke, Amy
- Laganas, Valerie A
- Loch, James T
- Miller, Matthew D
- Oguto, Herbert
- Patel, Sahil Joe
Producer: 20160718
In:
Bioorganic & medicinal chemistry letters vol. 25
Availability: No items available.
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11.
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Structure-guided design of potent and selective pyrimidylpyrrole inhibitors of extracellular signal-regulated kinase (ERK) using conformational control. [electronic resource] by
- Aronov, Alex M
- Tang, Qing
- Martinez-Botella, Gabriel
- Bemis, Guy W
- Cao, Jingrong
- Chen, Guanjing
- Ewing, Nigel P
- Ford, Pamella J
- Germann, Ursula A
- Green, Jeremy
- Hale, Michael R
- Jacobs, Marc
- Janetka, James W
- Maltais, Francois
- Markland, William
- Namchuk, Mark N
- Nanthakumar, Suganthini
- Poondru, Srinivasu
- Straub, Judy
- ter Haar, Ernst
- Xie, Xiaoling
Producer: 20091124
In:
Journal of medicinal chemistry vol. 52
Availability: No items available.
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12.
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Targeting the MAPK Signaling Pathway in Cancer: Promising Preclinical Activity with the Novel Selective ERK1/2 Inhibitor BVD-523 (Ulixertinib). [electronic resource] by
- Germann, Ursula A
- Furey, Brinley F
- Markland, William
- Hoover, Russell R
- Aronov, Alex M
- Roix, Jeffrey J
- Hale, Michael
- Boucher, Diane M
- Sorrell, David A
- Martinez-Botella, Gabriel
- Fitzgibbon, Matthew
- Shapiro, Paul
- Wick, Michael J
- Samadani, Ramin
- Meshaw, Kathryn
- Groover, Anna
- DeCrescenzo, Gary
- Namchuk, Mark
- Emery, Caroline M
- Saha, Saurabh
- Welsch, Dean J
Producer: 20180723
In:
Molecular cancer therapeutics vol. 16
Availability: No items available.
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13.
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In vivo validation of thymidylate kinase (TMK) with a rationally designed, selective antibacterial compound. [electronic resource] by
- Keating, Thomas A
- Newman, Joseph V
- Olivier, Nelson B
- Otterson, Linda G
- Andrews, Beth
- Boriack-Sjodin, P Ann
- Breen, John N
- Doig, Peter
- Dumas, Jacques
- Gangl, Eric
- Green, Oluyinka M
- Guler, Satenig Y
- Hentemann, Martin F
- Joseph-McCarthy, Diane
- Kawatkar, Sameer
- Kutschke, Amy
- Loch, James T
- McKenzie, Andrew R
- Pradeepan, Selvi
- Prasad, Swati
- Martínez-Botella, Gabriel
Producer: 20130417
In:
ACS chemical biology vol. 7
Availability: No items available.
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14.
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Discovery of selective and potent inhibitors of gram-positive bacterial thymidylate kinase (TMK). [electronic resource] by
- Martínez-Botella, Gabriel
- Breen, John N
- Duffy, James E S
- Dumas, Jacques
- Geng, Bolin
- Gowers, Ian K
- Green, Oluyinka M
- Guler, Satenig
- Hentemann, Martin F
- Hernandez-Juan, Felix A
- Joseph-McCarthy, Diane
- Kawatkar, Sameer
- Larsen, Nicholas A
- Lazari, Ovadia
- Loch, James T
- Macritchie, Jacqueline A
- McKenzie, Andrew R
- Newman, Joseph V
- Olivier, Nelson B
- Otterson, Linda G
- Owens, Andrew P
- Read, Jon
- Sheppard, David W
- Keating, Thomas A
Producer: 20130205
In:
Journal of medicinal chemistry vol. 55
Availability: No items available.
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15.
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Discovery of VX-509 (Decernotinib): A Potent and Selective Janus Kinase 3 Inhibitor for the Treatment of Autoimmune Diseases. [electronic resource] by
- Farmer, Luc J
- Ledeboer, Mark W
- Hoock, Thomas
- Arnost, Michael J
- Bethiel, Randy S
- Bennani, Youssef L
- Black, James J
- Brummel, Christopher L
- Chakilam, Ananthsrinivas
- Dorsch, Warren A
- Fan, Bin
- Cochran, John E
- Halas, Summer
- Harrington, Edmund M
- Hogan, James K
- Howe, David
- Huang, Hui
- Jacobs, Dylan H
- Laitinen, Leena M
- Liao, Shengkai
- Mahajan, Sudipta
- Marone, Valerie
- Martinez-Botella, Gabriel
- McCarthy, Pamela
- Messersmith, David
- Namchuk, Mark
- Oh, Luke
- Penney, Marina S
- Pierce, Albert C
- Raybuck, Scott A
- Rugg, Arthur
- Salituro, Francesco G
- Saxena, Kumkum
- Shannon, Dean
- Shlyakter, Dina
- Swenson, Lora
- Tian, Shi-Kai
- Town, Christopher
- Wang, Jian
- Wang, Tiansheng
- Wannamaker, M Woods
- Winquist, Raymond J
- Zuccola, Harmon J
Producer: 20151229
In:
Journal of medicinal chemistry vol. 58
Availability: No items available.
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