Mevalonate Pathway Provides Ubiquinone to Maintain Pyrimidine Synthesis and Survival in p53-Deficient Cancer Cells Exposed to Metabolic Stress. [electronic resource]
Producer: 20200619Description: 189-203 p. digitalISSN:- 1538-7445
- Animals
- Apoptosis
- Cell Line, Tumor
- Cell Survival
- Citric Acid Cycle -- drug effects
- Humans
- Hydroxymethylglutaryl-CoA Reductase Inhibitors -- pharmacology
- Intestinal Mucosa -- cytology
- Mevalonic Acid -- metabolism
- Mice
- Mice, Transgenic
- Neoplasms -- genetics
- Pyrimidines -- metabolism
- Signal Transduction -- drug effects
- Sterol Regulatory Element Binding Protein 2 -- metabolism
- Stress, Physiological
- Tumor Microenvironment -- genetics
- Tumor Suppressor Protein p53 -- genetics
- Ubiquinone -- analogs & derivatives
- Xenograft Model Antitumor Assays
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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