Resistance or sensitivity of Wilms' tumor to anti-FZD7 antibody highlights the Wnt pathway as a possible therapeutic target. [electronic resource]
Producer: 20110622Description: 1664-80 p. digitalISSN:- 1476-5594
- Adaptor Proteins, Signal Transducing
- Antibodies, Monoclonal -- pharmacology
- Antineoplastic Agents -- immunology
- Ataxia Telangiectasia Mutated Proteins
- Cell Cycle Proteins -- biosynthesis
- Flow Cytometry
- Frizzled Receptors -- immunology
- Gene Expression Regulation, Neoplastic
- Humans
- Intercellular Signaling Peptides and Proteins -- biosynthesis
- Kidney Neoplasms -- drug therapy
- Mutation
- Protein Serine-Threonine Kinases -- biosynthesis
- Receptors, G-Protein-Coupled -- immunology
- Tumor Cells, Cultured
- Tumor Suppressor Proteins -- genetics
- Wilms Tumor -- drug therapy
- Wnt Proteins -- metabolism
- beta Catenin -- biosynthesis
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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