Increased risk of vincristine neurotoxicity associated with low CYP3A5 expression genotype in children with acute lymphoblastic leukemia. [electronic resource]
Producer: 20110301Description: 361-7 p. digitalISSN:- 1545-5017
- Adolescent
- Black or African American
- Antineoplastic Agents, Phytogenic -- adverse effects
- Child
- Child, Preschool
- Cytochrome P-450 CYP3A -- genetics
- DNA, Neoplasm -- genetics
- Genotype
- Humans
- Infant
- Metabolic Clearance Rate
- Neurotoxicity Syndromes -- etiology
- Pharmacogenetics
- Polymerase Chain Reaction
- Precursor B-Cell Lymphoblastic Leukemia-Lymphoma -- drug therapy
- Tissue Distribution
- Vincristine -- adverse effects
- White People
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Publication Type: Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
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