Novel immunomodulator FTY720 is phosphorylated in rats and humans to form a single stereoisomer. Identification, chemical proof, and biological characterization of the biologically active species and its enantiomer. [electronic resource]
Producer: 20050927Description: 5373-7 p. digitalISSN:- 0022-2623
- Adjuvants, Immunologic -- blood
- Animals
- CHO Cells
- Chromatography, High Pressure Liquid
- Cricetinae
- Cricetulus
- Crystallography, X-Ray
- Fingolimod Hydrochloride
- Humans
- Male
- Organophosphates -- blood
- Phosphorylation
- Propylene Glycols -- blood
- Radioligand Assay
- Rats
- Rats, Wistar
- Receptors, Lysosphingolipid -- agonists
- Sphingosine -- analogs & derivatives
- Stereoisomerism
- Structure-Activity Relationship
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Publication Type: Journal Article
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