NMDA receptors mediate synaptic depression, but not spine loss in the dentate gyrus of adult amyloid Beta (Aβ) overexpressing mice. [electronic resource]
Producer: 20190612Description: 110 p. digitalISSN:- 2051-5960
- Action Potentials -- drug effects
- Alzheimer Disease -- genetics
- Amyloid beta-Peptides -- chemistry
- Amyloid beta-Protein Precursor -- genetics
- Animals
- Calcium-Calmodulin-Dependent Protein Kinase Type 2 -- genetics
- Dendritic Spines -- pathology
- Dentate Gyrus -- cytology
- Disease Models, Animal
- Excitatory Amino Acid Agents -- pharmacology
- Excitatory Postsynaptic Potentials -- drug effects
- Female
- Gene Expression Regulation -- drug effects
- HEK293 Cells
- Humans
- Male
- Mice
- Mice, Inbred C57BL
- Mice, Transgenic
- Mutation -- genetics
- Neurons -- drug effects
- Presenilin-1 -- genetics
- Receptors, N-Methyl-D-Aspartate -- genetics
- Synapses -- drug effects
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
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