Progression of BRAF-induced thyroid cancer is associated with epithelial-mesenchymal transition requiring concomitant MAP kinase and TGFβ signaling. [electronic resource]
Producer: 20110913Description: 3153-62 p. digitalISSN:- 1476-5594
- Animals
- Carcinoma
- Carcinoma, Papillary
- Cattle
- Disease Progression
- Enzyme Activation -- drug effects
- Epithelial-Mesenchymal Transition -- drug effects
- Gene Expression Profiling
- Humans
- MAP Kinase Signaling System -- drug effects
- Mice
- Mitogen-Activated Protein Kinases -- metabolism
- Organ Specificity
- Phosphorylation -- drug effects
- Proto-Oncogene Proteins B-raf -- genetics
- Smad2 Protein -- metabolism
- Thyroid Cancer, Papillary
- Thyroid Gland -- drug effects
- Thyroid Neoplasms -- genetics
- Transcription, Genetic -- drug effects
- Transforming Growth Factor beta -- metabolism
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
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