Proteolytic Cleavage of AMPKα and Intracellular MMP9 Expression Are Both Required for TLR4-Mediated mTORC1 Activation and HIF-1α Expression in Leukocytes. [electronic resource]
Producer: 20151215Description: 2452-60 p. digitalISSN:- 1550-6606
- AMP-Activated Protein Kinases -- metabolism
- Aged
- Animals
- Cells, Cultured
- Diabetes Mellitus, Type 2 -- blood
- Female
- Humans
- Hypoxia-Inducible Factor 1, alpha Subunit -- metabolism
- Immunoblotting
- Leukocytes -- drug effects
- Lipopolysaccharides -- pharmacology
- Male
- Matrix Metalloproteinase 9 -- metabolism
- Mechanistic Target of Rapamycin Complex 1
- Mice, Inbred C57BL
- Mice, Knockout
- Multiprotein Complexes -- metabolism
- Phosphorylation -- drug effects
- Proteolysis -- drug effects
- Ribosomal Protein S6 Kinases, 70-kDa -- metabolism
- Signal Transduction -- drug effects
- TOR Serine-Threonine Kinases -- metabolism
- Toll-Like Receptor 4 -- metabolism
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
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