Mapping of the structural determinants of artificial and biological membrane damaging activities of a Lys49 phospholipase A2 by scanning alanine mutagenesis. [electronic resource]
Producer: 20070607Description: 1247-57 p. digitalISSN:- 0006-3002
- Alanine -- metabolism
- Animals
- Bothrops -- metabolism
- Calcium -- metabolism
- Cell Membrane -- drug effects
- Cell Membrane Permeability -- drug effects
- Cells, Cultured
- Creatine Kinase -- blood
- Escherichia coli -- drug effects
- Liposomes
- Lysine -- metabolism
- Male
- Membranes, Artificial
- Mice
- Microbial Sensitivity Tests
- Models, Molecular
- Mutagenesis
- Mutant Proteins -- metabolism
- Phospholipases A -- chemistry
- Phospholipases A2
- Protein Structure, Secondary
- Snake Venoms -- enzymology
- Structure-Activity Relationship
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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