Systematic Dissection of the Metabolic-Apoptotic Interface in AML Reveals Heme Biosynthesis to Be a Regulator of Drug Sensitivity. [electronic resource]
Producer: 20200713Description: 1217-1231.e7 p. digitalISSN:- 1932-7420
- Antineoplastic Agents -- pharmacology
- Apoptosis -- drug effects
- Bridged Bicyclo Compounds, Heterocyclic -- pharmacology
- Drug Resistance, Neoplasm
- Electron Transport
- Electron Transport Chain Complex Proteins -- metabolism
- Gene Knockout Techniques
- HEK293 Cells
- Heme -- biosynthesis
- Humans
- Leukemia, Myeloid, Acute -- metabolism
- Membrane Potential, Mitochondrial -- drug effects
- Mitochondria -- drug effects
- Mitochondrial Membranes -- drug effects
- Proto-Oncogene Proteins c-bcl-2 -- antagonists & inhibitors
- Sulfonamides -- pharmacology
- THP-1 Cells
- Transduction, Genetic
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
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