Pracinostat (SB939), a histone deacetylase inhibitor, suppresses breast cancer metastasis and growth by inactivating the IL-6/STAT3 signalling pathways. [electronic resource]
Producer: 20200326Description: 117469 p. digitalISSN:- 1879-0631
- Animals
- Antigens, CD -- genetics
- Antineoplastic Agents -- pharmacology
- Benzimidazoles -- pharmacology
- Breast Neoplasms -- drug therapy
- Cadherins -- genetics
- Cell Line, Tumor
- Cell Movement -- drug effects
- Cell Proliferation -- drug effects
- Epithelial-Mesenchymal Transition -- drug effects
- Female
- Gene Expression Regulation, Neoplastic
- Histone Deacetylase Inhibitors -- pharmacology
- Histone Deacetylases -- genetics
- Histones -- genetics
- Humans
- Interleukin-6 -- genetics
- Lung Neoplasms -- drug therapy
- Mice
- Mice, Nude
- Repressor Proteins -- antagonists & inhibitors
- STAT3 Transcription Factor -- genetics
- Signal Transduction
- Tumor Burden -- drug effects
- Vimentin -- genetics
- Xenograft Model Antitumor Assays
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Publication Type: Journal Article
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