The flavonoid TL-2-8 induces cell death and immature mitophagy in breast cancer cells via abrogating the function of the AHA1/Hsp90 complex. [electronic resource]
Producer: 20180607Description: 1381-1393 p. digitalISSN:- 1745-7254
- Animals
- Antineoplastic Agents -- administration & dosage
- Breast Neoplasms -- drug therapy
- Cell Death -- drug effects
- Cell Line, Tumor
- Cell Proliferation -- drug effects
- Cell Survival -- drug effects
- Dose-Response Relationship, Drug
- Down-Regulation
- Female
- Flavonoids -- pharmacology
- HEK293 Cells
- HSP90 Heat-Shock Proteins -- metabolism
- Humans
- In Situ Nick-End Labeling
- Inhibitory Concentration 50
- MCF-7 Cells
- Mice
- Mice, Inbred BALB C
- Mice, Nude
- Mitophagy -- drug effects
- Molecular Chaperones -- metabolism
- Xenograft Model Antitumor Assays
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Publication Type: Journal Article
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