Single-cell RNA sequencing reveals compartmental remodeling of tumor-infiltrating immune cells induced by anti-CD47 targeting in pancreatic cancer. [electronic resource]
Producer: 20200706Description: 124 p. digitalISSN:- 1756-8722
- Adult
- Aged
- Aged, 80 and over
- Animals
- Antibodies, Monoclonal -- pharmacology
- Apoptosis
- Biomarkers, Tumor -- genetics
- CD47 Antigen -- antagonists & inhibitors
- CD8-Positive T-Lymphocytes -- drug effects
- Carcinoma, Pancreatic Ductal -- drug therapy
- Cell Proliferation
- Female
- Follow-Up Studies
- Gene Expression Regulation, Neoplastic
- Humans
- Immunotherapy
- Lymphocytes, Tumor-Infiltrating -- drug effects
- Male
- Mice
- Mice, Inbred BALB C
- Mice, Nude
- Middle Aged
- Molecular Targeted Therapy
- Pancreatic Neoplasms -- drug therapy
- Prognosis
- Single-Cell Analysis -- methods
- Survival Rate
- Tumor Cells, Cultured
- Tumor Microenvironment -- drug effects
- Xenograft Model Antitumor Assays
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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