Cdc7-Dbf4-mediated phosphorylation of HSP90-S164 stabilizes HSP90-HCLK2-MRN complex to enhance ATR/ATM signaling that overcomes replication stress in cancer. [electronic resource]
Producer: 20190805Description: 17024 p. digitalISSN:- 2045-2322
- Apoptosis
- Ataxia Telangiectasia Mutated Proteins -- genetics
- Biomarkers, Tumor -- genetics
- Carcinoma, Squamous Cell -- genetics
- Case-Control Studies
- Cell Cycle Proteins -- genetics
- Cell Proliferation
- DNA Replication
- Follow-Up Studies
- Gene Expression Regulation, Neoplastic
- HSP90 Heat-Shock Proteins -- genetics
- Humans
- Mouth Neoplasms -- genetics
- Phosphorylation
- Protein Serine-Threonine Kinases -- genetics
- Protein-Tyrosine Kinases -- genetics
- Signal Transduction
- Stress, Physiological
- Tumor Cells, Cultured
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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