VHL-HIF-2α axis-induced SMYD3 upregulation drives renal cell carcinoma progression via direct trans-activation of EGFR. [electronic resource]
Producer: 20201124Description: 4286-4298 p. digitalISSN:- 1476-5594
- Animals
- Basic Helix-Loop-Helix Transcription Factors -- genetics
- Carcinoma, Renal Cell -- genetics
- ErbB Receptors -- biosynthesis
- Gene Expression Regulation, Neoplastic
- Histone-Lysine N-Methyltransferase -- biosynthesis
- Humans
- Kidney Neoplasms -- genetics
- Male
- Mice
- Mice, Inbred BALB C
- Mice, Nude
- Neoplasm Proteins -- genetics
- Signal Transduction
- Transcriptional Activation
- Up-Regulation
- Von Hippel-Lindau Tumor Suppressor Protein -- genetics
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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