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Impact of the deltaF508 mutation in first nucleotide-binding domain of human cystic fibrosis transmembrane conductance regulator on domain folding and structure. [electronic resource] by
- Lewis, Hal A
- Zhao, Xun
- Wang, Chi
- Sauder, J Michael
- Rooney, Isabelle
- Noland, Brian W
- Lorimer, Don
- Kearins, Margaret C
- Conners, Kris
- Condon, Brad
- Maloney, Peter C
- Guggino, William B
- Hunt, John F
- Emtage, Spencer
Producer: 20050225
In:
The Journal of biological chemistry vol. 280
Availability: No items available.
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9.
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SGX393 inhibits the CML mutant Bcr-AblT315I and preempts in vitro resistance when combined with nilotinib or dasatinib. [electronic resource] by
- O'Hare, Thomas
- Eide, Christopher A
- Tyner, Jeffrey W
- Corbin, Amie S
- Wong, Matthew J
- Buchanan, Sean
- Holme, Kevin
- Jessen, Katayoun A
- Tang, Crystal
- Lewis, Hal A
- Romero, Richard D
- Burley, Stephen K
- Deininger, Michael W
Producer: 20080610
In:
Proceedings of the National Academy of Sciences of the United States of America vol. 105
Availability: No items available.
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10.
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Discovery of S3-Truncated, C-6 Heteroaryl Substituted Aminothiazine β-Site APP Cleaving Enzyme-1 (BACE1) Inhibitors. [electronic resource] by
- Wu, Yong-Jin
- Guernon, Jason
- Shi, Jianliang
- Marcin, Lawrence
- Higgins, Mendi
- Rajamani, Ramkumar
- Muckelbauer, Jodi
- Lewis, Hal
- Chang, ChiehYing
- Camac, Dan
- Toyn, Jeremy H
- Ahlijanian, Michael K
- Albright, Charles F
- Macor, John E
- Thompson, Lorin A
Producer: 20170612
In:
Journal of medicinal chemistry vol. 59
Availability: No items available.
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11.
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Immune-modulating enzyme indoleamine 2,3-dioxygenase is effectively inhibited by targeting its apo-form. [electronic resource] by
- Nelp, Micah T
- Kates, Patrick A
- Hunt, John T
- Newitt, John A
- Balog, Aaron
- Maley, Derrick
- Zhu, Xiao
- Abell, Lynn
- Allentoff, Alban
- Borzilleri, Robert
- Lewis, Hal A
- Lin, Zeyu
- Seitz, Steven P
- Yan, Chunhong
- Groves, John T
Producer: 20180806
In:
Proceedings of the National Academy of Sciences of the United States of America vol. 115
Availability: No items available.
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12.
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Targeting the BACE1 Active Site Flap Leads to a Potent Inhibitor That Elicits Robust Brain Aβ Reduction in Rodents. [electronic resource] by
- Wu, Yong-Jin
- Guernon, Jason
- Yang, Fukang
- Snyder, Lawrence
- Shi, Jianliang
- Mcclure, Andrea
- Rajamani, Ramkumar
- Park, Hyunsoo
- Ng, Alicia
- Lewis, Hal
- Chang, ChiehYing
- Camac, Dan
- Toyn, Jeremy H
- Ahlijanian, Michael K
- Albright, Charles F
- Macor, John E
- Thompson, Lorin A
Producer: 20160317
In:
ACS medicinal chemistry letters vol. 7
Availability: No items available.
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13.
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Channel Gating Regulation by the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) First Cytosolic Loop. [electronic resource] by
- Ehrhardt, Annette
- Chung, W Joon
- Pyle, Louise C
- Wang, Wei
- Nowotarski, Krzysztof
- Mulvihill, Cory M
- Ramjeesingh, Mohabir
- Hong, Jeong
- Velu, Sadanandan E
- Lewis, Hal A
- Atwell, Shane
- Aller, Steve
- Bear, Christine E
- Lukacs, Gergely L
- Kirk, Kevin L
- Sorscher, Eric J
Producer: 20160822
In:
The Journal of biological chemistry vol. 291
Availability: No items available.
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14.
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Structures of a minimal human CFTR first nucleotide-binding domain as a monomer, head-to-tail homodimer, and pathogenic mutant. [electronic resource] by
- Atwell, Shane
- Brouillette, Christie G
- Conners, Kris
- Emtage, Spencer
- Gheyi, Tarun
- Guggino, William B
- Hendle, Jorg
- Hunt, John F
- Lewis, Hal A
- Lu, Frances
- Protasevich, Irina I
- Rodgers, Logan A
- Romero, Rich
- Wasserman, Stephen R
- Weber, Patricia C
- Wetmore, Diana
- Zhang, Feiyu F
- Zhao, Xun
Producer: 20100818
In:
Protein engineering, design & selection : PEDS vol. 23
Availability: No items available.
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15.
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Discovery of Isonicotinamides as Highly Selective, Brain Penetrable, and Orally Active Glycogen Synthase Kinase-3 Inhibitors. [electronic resource] by
- Luo, Guanglin
- Chen, Ling
- Burton, Catherine R
- Xiao, Hong
- Sivaprakasam, Prasanna
- Krause, Carol M
- Cao, Yang
- Liu, Nengyin
- Lippy, Jonathan
- Clarke, Wendy J
- Snow, Kimberly
- Raybon, Joseph
- Arora, Vinod
- Pokross, Matt
- Kish, Kevin
- Lewis, Hal A
- Langley, David R
- Macor, John E
- Dubowchik, Gene M
Producer: 20160712
In:
Journal of medicinal chemistry vol. 59
Availability: No items available.
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16.
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Discovery and Optimization of Novel Pyrazolopyrimidines as Potent and Orally Bioavailable Allosteric HIV-1 Integrase Inhibitors. [electronic resource] by
- Li, Guo
- Meanwell, Nicholas A
- Krystal, Mark R
- Langley, David R
- Naidu, B Narasimhulu
- Sivaprakasam, Prasanna
- Lewis, Hal
- Kish, Kevin
- Khan, Javed A
- Ng, Alicia
- Trainor, George L
- Cianci, Christopher
- Dicker, Ira B
- Walker, Michael A
- Lin, Zeyu
- Protack, Tricia
- Discotto, Linda
- Jenkins, Susan
- Gerritz, Samuel W
- Pendri, Annapurna
Producer: 20200831
In:
Journal of medicinal chemistry vol. 63
Availability: No items available.
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17.
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Discovery of new acylaminopyridines as GSK-3 inhibitors by a structure guided in-depth exploration of chemical space around a pyrrolopyridinone core. [electronic resource] by
- Sivaprakasam, Prasanna
- Han, Xiaojun
- Civiello, Rita L
- Jacutin-Porte, Swanee
- Kish, Kevin
- Pokross, Matt
- Lewis, Hal A
- Ahmed, Nazia
- Szapiel, Nicolas
- Newitt, John A
- Baldwin, Eric T
- Xiao, Hong
- Krause, Carol M
- Park, Hyunsoo
- Nophsker, Michelle
- Lippy, Jonathan S
- Burton, Catherine R
- Langley, David R
- Macor, John E
- Dubowchik, Gene M
Producer: 20160219
In:
Bioorganic & medicinal chemistry letters vol. 25
Availability: No items available.
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18.
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5,6,7,8-Tetrahydro-1,6-naphthyridine Derivatives as Potent HIV-1-Integrase-Allosteric-Site Inhibitors. [electronic resource] by
- Peese, Kevin M
- Allard, Christopher W
- Connolly, Timothy
- Johnson, Barry L
- Li, Chen
- Patel, Manoj
- Sorensen, Margaret E
- Walker, Michael A
- Meanwell, Nicholas A
- McAuliffe, Brian
- Minassian, Beatrice
- Krystal, Mark
- Parker, Dawn D
- Lewis, Hal A
- Kish, Kevin
- Zhang, Ping
- Nolte, Robert T
- Simmermacher, Jean
- Jenkins, Susan
- Cianci, Christopher
- Naidu, B Narasimhulu
Producer: 20200303
In:
Journal of medicinal chemistry vol. 62
Availability: No items available.
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19.
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Initial Clinical Guidelines for Co-Occurring Autism Spectrum Disorder and Gender Dysphoria or Incongruence in Adolescents. [electronic resource] by
- Strang, John F
- Meagher, Haley
- Kenworthy, Lauren
- de Vries, Annelou L C
- Menvielle, Edgardo
- Leibowitz, Scott
- Janssen, Aron
- Cohen-Kettenis, Peggy
- Shumer, Daniel E
- Edwards-Leeper, Laura
- Pleak, Richard R
- Spack, Norman
- Karasic, Dan H
- Schreier, Herbert
- Balleur, Anouk
- Tishelman, Amy
- Ehrensaft, Diane
- Rodnan, Leslie
- Kuschner, Emily S
- Mandel, Francie
- Caretto, Antonia
- Lewis, Hal C
- Anthony, Laura G
Producer: 20190326
In:
Journal of clinical child and adolescent psychology : the official journal for the Society of Clinical Child and Adolescent Psychology, American Psychological Association, Division 53 vol. 47
Availability: No items available.
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20.
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Structure of nucleotide-binding domain 1 of the cystic fibrosis transmembrane conductance regulator. [electronic resource] by
- Lewis, Hal A
- Buchanan, Sean G
- Burley, Stephen K
- Conners, Kris
- Dickey, Mark
- Dorwart, Michael
- Fowler, Richard
- Gao, Xia
- Guggino, William B
- Hendrickson, Wayne A
- Hunt, John F
- Kearins, Margaret C
- Lorimer, Don
- Maloney, Peter C
- Post, Kai W
- Rajashankar, Kanagalaghatta R
- Rutter, Marc E
- Sauder, J Michael
- Shriver, Stephanie
- Thibodeau, Patrick H
- Thomas, Philip J
- Zhang, Marie
- Zhao, Xun
- Emtage, Spencer
Producer: 20040813
In:
The EMBO journal vol. 23
Availability: No items available.
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