Your search returned 33 results.

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	1.	Improving prediction of torsadogenic risk in the CiPA in silico model by appropriately accounting for clinical exposure. [electronic resource] by Leishman, Derek J Producer: 20201113 In: Journal of pharmacological and toxicological methods vol. 101 Online resources: Available from publisher's website Availability: No items available. Save to lists Add to cart (remove)
	2.	Real estate diagrams: A tool to quickly assess the utility of a new predictive technology. [electronic resource] by Felli, James C Leishman, Derek J Publication details: Journal of pharmacological and toxicological methods In: Journal of pharmacological and toxicological methods vol. 99 Online resources: Available from publisher's website Availability: No items available. Save to lists Add to cart (remove)
	3.	Towards a drug concentration effect relationship for QT prolongation and torsades de pointes. [electronic resource] by Webster, Rob Leishman, Derek Walker, Don Producer: 20020812 In: Current opinion in drug discovery & development vol. 5 Availability: No items available. Save to lists Add to cart (remove)
	4.	Relationship of clinical adverse event reports to models of arrhythmia risk. [electronic resource] by Ether, Nicholas Leishman, Derek Bailie, Marc Lauver, Adam Producer: 20200327 In: Journal of pharmacological and toxicological methods vol. 100 Online resources: Available from publisher's website Availability: No items available. Save to lists Add to cart (remove)
	5.	A one-step approach to the analysis of the QT interval in conscious telemetrized dogs. [electronic resource] by Chiang, Alan Y Holdsworth, David L Leishman, Derek J Producer: 20061019 In: Journal of pharmacological and toxicological methods vol. 54 Online resources: Available from publisher's website Availability: No items available. Save to lists Add to cart (remove)
	6.	Utility of positive controls in assessing assay sensitivity in ICH S7B and ICH E14 guidance for evaluation of QT/QTc interval prolongation. [electronic resource] by Chiang, Alan Y Mallinckrodt, Craig H Dmitrienko, Alex A Leishman, Derek J Producer: 20110208 In: Journal of pharmacological and toxicological methods vol. 62 Online resources: Available from publisher's website Availability: No items available. Save to lists Add to cart (remove)
	7.	Towards automation of a valuable preclinical cardiac safety pharmacology assay: Evaluation of the effects of cardiac ion channel blockers on cardiac repolarisation in vitro. [electronic resource] by Lightbown, Ian D Johnson, Mark Davis, Anne Leaney, Joanne Leishman, Derek J Producer: 20080229 In: Journal of pharmacological and toxicological methods vol. 56 Online resources: Available from publisher's website Availability: No items available. Save to lists Add to cart (remove)
	8.	Heartbeat dynamics in adrenergic blocker treated conscious beagle dogs. [electronic resource] by Li, Dingzhou Chiang, Alan Y Clawson, Christine A Main, Bradley W Leishman, Derek J Producer: 20090129 In: Journal of pharmacological and toxicological methods vol. 58 Online resources: Available from publisher's website Availability: No items available. Save to lists Add to cart (remove)
	9.	hERG K+ channel blockade by the antipsychotic drug thioridazine: An obligatory role for the S6 helix residue F656. [electronic resource] by Milnes, James T Witchel, Harry J Leaney, Joanne L Leishman, Derek J Hancox, Jules C Producer: 20061222 In: Biochemical and biophysical research communications vol. 351 Online resources: Available from publisher's website Availability: No items available. Save to lists Add to cart (remove)
	10.	The relationship of clinical QT prolongation to outcome in the conscious dog using a beat-to-beat QT-RR interval assessment. [electronic resource] by Fossa, Anthony A DePasquale, Michael J Raunig, David L Avery, Michael J Leishman, Derek J Producer: 20020829 In: The Journal of pharmacology and experimental therapeutics vol. 302 Online resources: Available from publisher's website Availability: No items available. Save to lists Add to cart (remove)
	11.	Investigating dynamic protocol-dependence of hERG potassium channel inhibition at 37 degrees C: Cisapride versus dofetilide. [electronic resource] by Milnes, James T Witchel, Harry J Leaney, Joanne L Leishman, Derek J Hancox, Jules C Producer: 20100617 In: Journal of pharmacological and toxicological methods vol. 61 Online resources: Available from publisher's website Availability: No items available. Save to lists Add to cart (remove)
	12.	A pharmacokinetic-pharmacodynamic model for the quantitative prediction of dofetilide clinical QT prolongation from human ether-a-go-go-related gene current inhibition data. [electronic resource] by Jonker, Daniël M Kenna, Leslie A Leishman, Derek Wallis, Rob Milligan, Peter A Jonsson, E Niclas Producer: 20050719 In: Clinical pharmacology and therapeutics vol. 77 Online resources: Available from publisher's website Availability: No items available. Save to lists Add to cart (remove)
	13.	Impact of study design on proarrhythmia prediction in the SCREENIT rabbit isolated heart model. [electronic resource] by Steidl-Nichols, Jill V Hanton, Gilles Leaney, Joanne Liu, Ruei-Che Leishman, Derek McHarg, Aileen Wallis, Rob Producer: 20081027 In: Journal of pharmacological and toxicological methods vol. 57 Online resources: Available from publisher's website Availability: No items available. Save to lists Add to cart (remove)
	14.	Structural determinants of HERG channel block by clofilium and ibutilide. [electronic resource] by Perry, Matthew de Groot, Marcel J Helliwell, Ray Leishman, Derek Tristani-Firouzi, Martin Sanguinetti, Michael C Mitcheson, John Producer: 20040830 In: Molecular pharmacology vol. 66 Online resources: Available from publisher's website Availability: No items available. Save to lists Add to cart (remove)
	15.	Overcoming HERG affinity in the discovery of the CCR5 antagonist maraviroc. [electronic resource] by Price, David A Armour, Duncan de Groot, Marcel Leishman, Derek Napier, Carolyn Perros, Manos Stammen, Blanda L Wood, Anthony Producer: 20061016 In: Bioorganic & medicinal chemistry letters vol. 16 Online resources: Available from publisher's website Availability: No items available. Save to lists Add to cart (remove)
	16.	Overcoming hERG affinity in the discovery of maraviroc; a CCR5 antagonist for the treatment of HIV. [electronic resource] by Price, David A Armour, Duncan de Groot, Marcel Leishman, Derek Napier, Carolyn Perros, Manos Stammen, Blanda L Wood, Anthony Producer: 20090312 In: Current topics in medicinal chemistry vol. 8 Online resources: Available from publisher's website Availability: No items available. Save to lists Add to cart (remove)
	17.	Mechanism of hERG K+ channel blockade by the fluoroquinolone antibiotic moxifloxacin. [electronic resource] by Alexandrou, Ari J Duncan, Rona S Sullivan, Anneli Hancox, Jules C Leishman, Derek J Witchel, Harry J Leaney, Joanne L Producer: 20070104 In: British journal of pharmacology vol. 147 Online resources: Available from publisher's website Availability: No items available. Save to lists Add to cart (remove)
	18.	Gastrointestinal Safety Pharmacology in Drug Discovery and Development. [electronic resource] by Al-Saffar, Ahmad Nogueira da Costa, André Delaunois, Annie Leishman, Derek J Marks, Louise Rosseels, Marie-Luce Valentin, J-P Producer: 20150910 In: Handbook of experimental pharmacology vol. 229 Online resources: Available from publisher's website Availability: No items available. Save to lists Add to cart (remove)
	19.	Drug binding interactions in the inner cavity of HERG channels: molecular insights from structure-activity relationships of clofilium and ibutilide analogs. [electronic resource] by Perry, Matthew Stansfeld, Phillip J Leaney, Joanne Wood, Claire de Groot, Marcel J Leishman, Derek Sutcliffe, Michael J Mitcheson, John S Producer: 20060310 In: Molecular pharmacology vol. 69 Online resources: Available from publisher's website Availability: No items available. Save to lists Add to cart (remove)
	20.	Erythromycin block of the HERG K+ channel: accessibility to F656 and Y652. [electronic resource] by Duncan, Rona S Ridley, John M Dempsey, Christopher E Leishman, Derek J Leaney, Joanne L Hancox, Jules C Witchel, Harry J Producer: 20060418 In: Biochemical and biophysical research communications vol. 341 Online resources: Available from publisher's website Availability: No items available. Save to lists Add to cart (remove)

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Your search returned 33 results.