Discovery of tankyrase inhibiting flavones with increased potency and isoenzyme selectivity. [electronic resource]
Producer: 20140310Description: 7880-9 p. digitalISSN:- 1520-4804
- Animals
- Crystallography, X-Ray
- Drug Discovery
- Flavones -- chemistry
- HEK293 Cells
- Heterocyclic Compounds, 3-Ring -- chemistry
- Humans
- Isoenzymes -- antagonists & inhibitors
- L Cells
- Mice
- Models, Molecular
- Molecular Structure
- Poly(ADP-ribose) Polymerase Inhibitors
- Poly(ADP-ribose) Polymerases -- chemistry
- Protein Binding
- Protein Structure, Tertiary
- Tankyrases -- antagonists & inhibitors
- Wnt Signaling Pathway -- drug effects
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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