Pharmacokinetic and pharmacogenetic determinants of the activity and toxicity of irinotecan in metastatic colorectal cancer patients. [electronic resource]
Producer: 20081104Description: 1239-45 p. digitalISSN:- 1532-1827
- Adult
- Aged
- Antineoplastic Agents, Phytogenic -- blood
- Area Under Curve
- Camptothecin -- analogs & derivatives
- Carboxylesterase -- genetics
- Chromatography, High Pressure Liquid
- Colonic Neoplasms -- drug therapy
- Female
- Glucuronides -- blood
- Glucuronosyltransferase -- genetics
- Humans
- Irinotecan
- Male
- Middle Aged
- Polymerase Chain Reaction
- Polymorphism, Genetic
- Promoter Regions, Genetic -- genetics
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Publication Type: Clinical Trial; Journal Article
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