Application of a MYC degradation screen identifies sensitivity to CDK9 inhibitors in KRAS-mutant pancreatic cancer. [electronic resource]
Producer: 20200807ISSN:- 1937-9145
- Cell Line, Tumor
- Cell Proliferation -- drug effects
- Cyclin-Dependent Kinase 9 -- antagonists & inhibitors
- Drug Screening Assays, Antitumor -- methods
- Gene Expression Regulation, Neoplastic -- drug effects
- Humans
- Molecular Structure
- Mutation
- Pancreatic Neoplasms -- genetics
- Phosphorylation -- drug effects
- Protein Kinase Inhibitors -- chemistry
- Protein Stability
- Proteolysis
- Proto-Oncogene Proteins c-myc -- genetics
- Proto-Oncogene Proteins p21(ras) -- genetics
- Small Molecule Libraries -- chemistry
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
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