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Terbinafine is a novel and selective activator of the two-pore domain potassium channel TASK3. [electronic resource] by
- Wright, Paul D
- Veale, Emma L
- McCoull, David
- Tickle, David C
- Large, Jonathan M
- Ococks, Emma
- Gothard, Gemma
- Kettleborough, Catherine
- Mathie, Alistair
- Jerman, Jeffrey
Producer: 20171023
In:
Biochemical and biophysical research communications vol. 493
Availability: No items available.
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Pranlukast is a novel small molecule activator of the two-pore domain potassium channel TREK2. [electronic resource] by
- Wright, Paul D
- McCoull, David
- Walsh, Yvonne
- Large, Jonathan M
- Hadrys, Barbara W
- Gaurilcikaite, Egle
- Byrom, Lewis
- Veale, Emma L
- Jerman, Jeff
- Mathie, Alistair
Producer: 20200623
In:
Biochemical and biophysical research communications vol. 520
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Structure-based design of imidazo[1,2-a]pyrazine derivatives as selective inhibitors of Aurora-A kinase in cells. [electronic resource] by
- Bouloc, Nathalie
- Large, Jonathan M
- Kosmopoulou, Magda
- Sun, Chongbo
- Faisal, Amir
- Matteucci, Mizio
- Reynisson, Jóhannes
- Brown, Nathan
- Atrash, Butrus
- Blagg, Julian
- McDonald, Edward
- Linardopoulos, Spiros
- Bayliss, Richard
- Bavetsias, Vassilios
Producer: 20110113
In:
Bioorganic & medicinal chemistry letters vol. 20
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Preparation and evaluation of trisubstituted pyrimidines as phosphatidylinositol 3-kinase inhibitors. 3-Hydroxyphenol analogues and bioisosteric replacements. [electronic resource] by
- Large, Jonathan M
- Torr, Jane E
- Raynaud, Florence I
- Clarke, Paul A
- Hayes, Angela
- Stefano, Francesca di
- Urban, Frederique
- Shuttleworth, Stephen J
- Saghir, Nahid
- Sheldrake, Peter
- Workman, Paul
- McDonald, Edward
Producer: 20110503
In:
Bioorganic & medicinal chemistry vol. 19
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Substituted imidazopyridazines are potent and selective inhibitors of Plasmodium falciparum calcium-dependent protein kinase 1 (PfCDPK1). [electronic resource] by
- Chapman, Timothy M
- Osborne, Simon A
- Bouloc, Nathalie
- Large, Jonathan M
- Wallace, Claire
- Birchall, Kristian
- Ansell, Keith H
- Jones, Hayley M
- Taylor, Debra
- Clough, Barbara
- Green, Judith L
- Holder, Anthony A
Producer: 20131126
In:
Bioorganic & medicinal chemistry letters vol. 23
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Trisubstituted thiazoles as potent and selective inhibitors of Plasmodium falciparum protein kinase G (PfPKG). [electronic resource] by
- Tsagris, Denise J
- Birchall, Kristian
- Bouloc, Nathalie
- Large, Jonathan M
- Merritt, Andy
- Smiljanic-Hurley, Ela
- Wheldon, Mary
- Ansell, Keith H
- Kettleborough, Catherine
- Whalley, David
- Stewart, Lindsay B
- Bowyer, Paul W
- Baker, David A
- Osborne, Simon A
Producer: 20190522
In:
Bioorganic & medicinal chemistry letters vol. 28
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13.
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Potent bicyclic inhibitors of malarial cGMP-dependent protein kinase: approaches to combining improvements in cell potency, selectivity and structural novelty. [electronic resource] by
- Large, Jonathan M
- Birchall, Kristian
- Bouloc, Nathalie S
- Merritt, Andy T
- Smiljanic-Hurley, Ela
- Tsagris, Denise J
- Wheldon, Mary C
- Ansell, Keith H
- Coombs, Peter J
- Kettleborough, Catherine A
- Whalley, David
- Stewart, Lindsay B
- Bowyer, Paul W
- Baker, David A
- Osborne, Simon A
Producer: 20200921
In:
Bioorganic & medicinal chemistry letters vol. 29
Availability: No items available.
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Potent inhibitors of malarial P. Falciparum protein kinase G: Improving the cell activity of a series of imidazopyridines. [electronic resource] by
- Large, Jonathan M
- Birchall, Kristian
- Bouloc, Nathalie S
- Merritt, Andy T
- Smiljanic-Hurley, Ela
- Tsagris, Denise J
- Wheldon, Mary C
- Ansell, Keith H
- Coombs, Peter J
- Kettleborough, Catherine A
- Whalley, David
- Stewart, Lindsay B
- Bowyer, Paul W
- Baker, David A
- Osborne, Simon A
Producer: 20191209
In:
Bioorganic & medicinal chemistry letters vol. 29
Availability: No items available.
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15.
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Imidazo[4,5-b]pyridine derivatives as inhibitors of Aurora kinases: lead optimization studies toward the identification of an orally bioavailable preclinical development candidate. [electronic resource] by
- Bavetsias, Vassilios
- Large, Jonathan M
- Sun, Chongbo
- Bouloc, Nathalie
- Kosmopoulou, Magda
- Matteucci, Mizio
- Wilsher, Nicola E
- Martins, Vanessa
- Reynisson, Jóhannes
- Atrash, Butrus
- Faisal, Amir
- Urban, Frederique
- Valenti, Melanie
- de Haven Brandon, Alexis
- Box, Gary
- Raynaud, Florence I
- Workman, Paul
- Eccles, Suzanne A
- Bayliss, Richard
- Blagg, Julian
- Linardopoulos, Spiros
- McDonald, Edward
Producer: 20100825
In:
Journal of medicinal chemistry vol. 53
Availability: No items available.
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A potent series targeting the malarial cGMP-dependent protein kinase clears infection and blocks transmission. [electronic resource] by
- Baker, David A
- Stewart, Lindsay B
- Large, Jonathan M
- Bowyer, Paul W
- Ansell, Keith H
- Jiménez-Díaz, María B
- El Bakkouri, Majida
- Birchall, Kristian
- Dechering, Koen J
- Bouloc, Nathalie S
- Coombs, Peter J
- Whalley, David
- Harding, Denise J
- Smiljanic-Hurley, Ela
- Wheldon, Mary C
- Walker, Eloise M
- Dessens, Johannes T
- Lafuente, María José
- Sanz, Laura M
- Gamo, Francisco-Javier
- Ferrer, Santiago B
- Hui, Raymond
- Bousema, Teun
- Angulo-Barturén, Iñigo
- Merritt, Andy T
- Croft, Simon L
- Gutteridge, Winston E
- Kettleborough, Catherine A
- Osborne, Simon A
Producer: 20180108
In:
Nature communications vol. 8
Availability: No items available.
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